Complexity of vesicle microcirculation

B. Kaoui, N. Tahiri, T. Biben, H. Ez-Zahraouy, A. Benyoussef, G. Biros, C. Misbah

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Abstract

This study focuses numerically on dynamics in two dimensions of vesicles in microcirculation. The method used is based on boundary integral formulation. This study is inspired by the behavior of red blood cells (RBCs) in the microvasculature. Red RBCs carry oxygen from the lungs and deliver it through the microvasculature. The shape adopted by RBCs can affect blood flow and influence oxygen delivery. Our simulation using vesicles (a simple model for RBC) reveals unexpected complexity as compared to the case where a purely unbounded Poiseuille flow is considered [ Phys. Rev. Lett. 103 188101 (2009)]. In sufficiently large channels (in the range of 100 µm; the vesicle size and its reduced volume are taken in the range of those of a human RBC), such as arterioles, a slipperlike (asymmetric) shape prevails. A parachutelike (symmetric) shape is adopted in smaller channels (in the range of 20 µm, as in venules), but this shape loses stability and again changes to a pronounced slipperlike morphology in channels having a size typical of capillaries (5–10 µm). Stiff membranes, mimicking malaria infection, for example, adopt a centered or off-centered snakelike locomotion instead (the denomination snaking is used for this regime). A general scenario of how and why vesicles adopt their morphologies and dynamics among several distinct possibilities is provided. This finding potentially points to nontrivial RBCs dynamics in the microvasculature.
Original languageEnglish
Article number041906
Pages (from-to)041906-1/5
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume84
Issue number4
DOIs
Publication statusPublished - 2011

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    Kaoui, B., Tahiri, N., Biben, T., Ez-Zahraouy, H., Benyoussef, A., Biros, G., & Misbah, C. (2011). Complexity of vesicle microcirculation. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 84(4), 041906-1/5. [041906]. https://doi.org/10.1103/PhysRevE.84.041906