Complex flow patterns in a real-size intracranial aneurysm phantom: phase contrast MRI compared with particle image velocimetry and computational fluid dynamics

P. van Ooij, A. Guedon, C. Poelma, J. Schneiders, M.C.M. Rutten, H.A. Marquering, C.B. Majoie, E.T. VanBavel, A.J. Nederveen

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Abstract

The aim of this study was to validate the flow patterns measured by high-resolution, time-resolved, three-dimensional phase contrast MRI in a real-size intracranial aneurysm phantom. Retrospectively gated three-dimensional phase contrast MRI was performed in an intracranial aneurysm phantom at a resolution of 0.2x0.2x0.3mm3 in a solenoid rat coil. Both steady and pulsatile flows were applied. The phase contrast MRI measurements were compared with particle image velocimetry measurements and computational fluid dynamics simulations. A quantitative comparison was performed by calculating the differences between the magnitude of the velocity vectors and angles between the velocity vectors in corresponding voxels. Qualitative analysis of the results was executed by visual inspection and comparison of the flow patterns. The root-mean-square errors of the velocity magnitude in the comparison between phase contrast MRI and computational fluid dynamics were 5% and 4% of the maximum phase contrast MRI velocity, and the medians of the angle distribution between corresponding velocity vectors were 16 degrees and 14 degrees for the steady and pulsatile measurements, respectively. In the phase contrast MRI and particle image velocimetry comparison, the root-mean-square errors were 12% and 10% of the maximum phase contrast MRI velocity, and the medians of the angle distribution between corresponding velocity vectors were 19 degrees and 15 degrees for the steady and pulsatile measurements, respectively. Good agreement was found in the qualitative comparison of flow patterns between the phase contrast MRI measurements and both particle image velocimetry measurements and computational fluid dynamics simulations. High-resolution, time-resolved, three-dimensional phase contrast MRI can accurately measure complex flow patterns in an intracranial aneurysm phantom. Copyright (c) 2011 John Wiley & Sons, Ltd
Original languageEnglish
Pages (from-to)14-26
JournalNMR in Biomedicine
Volume25
Issue number1
DOIs
Publication statusPublished - 2012

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Rheology
Intracranial Aneurysm
Hydrodynamics
Velocity measurement
Flow patterns
Magnetic resonance imaging
Computational fluid dynamics
Pulsatile Flow
Nuclear Family
Mean square error
Pulsatile flow
Solenoids
Computer simulation
Steady flow
Rats
Inspection

Cite this

van Ooij, P. ; Guedon, A. ; Poelma, C. ; Schneiders, J. ; Rutten, M.C.M. ; Marquering, H.A. ; Majoie, C.B. ; VanBavel, E.T. ; Nederveen, A.J. / Complex flow patterns in a real-size intracranial aneurysm phantom: phase contrast MRI compared with particle image velocimetry and computational fluid dynamics. In: NMR in Biomedicine. 2012 ; Vol. 25, No. 1. pp. 14-26.
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abstract = "The aim of this study was to validate the flow patterns measured by high-resolution, time-resolved, three-dimensional phase contrast MRI in a real-size intracranial aneurysm phantom. Retrospectively gated three-dimensional phase contrast MRI was performed in an intracranial aneurysm phantom at a resolution of 0.2x0.2x0.3mm3 in a solenoid rat coil. Both steady and pulsatile flows were applied. The phase contrast MRI measurements were compared with particle image velocimetry measurements and computational fluid dynamics simulations. A quantitative comparison was performed by calculating the differences between the magnitude of the velocity vectors and angles between the velocity vectors in corresponding voxels. Qualitative analysis of the results was executed by visual inspection and comparison of the flow patterns. The root-mean-square errors of the velocity magnitude in the comparison between phase contrast MRI and computational fluid dynamics were 5{\%} and 4{\%} of the maximum phase contrast MRI velocity, and the medians of the angle distribution between corresponding velocity vectors were 16 degrees and 14 degrees for the steady and pulsatile measurements, respectively. In the phase contrast MRI and particle image velocimetry comparison, the root-mean-square errors were 12{\%} and 10{\%} of the maximum phase contrast MRI velocity, and the medians of the angle distribution between corresponding velocity vectors were 19 degrees and 15 degrees for the steady and pulsatile measurements, respectively. Good agreement was found in the qualitative comparison of flow patterns between the phase contrast MRI measurements and both particle image velocimetry measurements and computational fluid dynamics simulations. High-resolution, time-resolved, three-dimensional phase contrast MRI can accurately measure complex flow patterns in an intracranial aneurysm phantom. Copyright (c) 2011 John Wiley & Sons, Ltd",
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Complex flow patterns in a real-size intracranial aneurysm phantom: phase contrast MRI compared with particle image velocimetry and computational fluid dynamics. / van Ooij, P.; Guedon, A.; Poelma, C.; Schneiders, J.; Rutten, M.C.M.; Marquering, H.A.; Majoie, C.B.; VanBavel, E.T.; Nederveen, A.J.

In: NMR in Biomedicine, Vol. 25, No. 1, 2012, p. 14-26.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Poelma, C.

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AU - Rutten, M.C.M.

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