Complex dynamics of a bilamellar vesicle as a simple model for leukocytes

B. Kaoui, T. Krüger, J.D.R. Harting

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    The influence of the internal structure of a biological cell (e.g., a leukocyte) on its dynamics and rheology is not yet fully understood. By using 2D numerical simulations of a bilamellar vesicle (BLV) consisting of two vesicles as a cell model, we find that increasing the size of the inner vesicle (mimicking the nucleus) triggers a tank-treading-to-tumbling transition. A new dynamical state is observed, the undulating motion: the BLV inclination with respect to the imposed flow oscillates while the outer vesicle develops rotating lobes. The BLV exhibits a non-Newtonian behavior with a time-dependant apparent viscosity during its unsteady motion. Depending on its inclination and on its inner vesicle dynamical state, the BLV behaves like a solid or a liquid.
    Original languageEnglish
    Pages (from-to)8057-8061
    Number of pages7
    JournalSoft Matter
    Issue number33
    Publication statusPublished - 2013


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