Comparison between electrocardiogram- and photoplethysmogram-derived features for atrial fibrillation detection in free-living conditions

Linda M. Eerikäinen, Alberto G. Bonomi, Fons Schipper, Lukas R.C. Dekker, Rik Vullings, Helma M. de Morree, Ronald M. Aarts

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Abstract

OBJECTIVE: Atrial fibrillation (AF) is the most commonly experienced arrhythmia and it increases the risk of stroke and heart failure. The challenge in detecting the presence of AF is the occasional and asymptomatic manifestation of the condition. Long-term monitoring can increase the sensitivity of detecting intermittent AF episodes, however it is either cumbersome or invasive and costly with electrocardiography (ECG). Photoplethysmography (PPG) is an unobtrusive measuring modality enabling heart rate monitoring, and promising results have been presented in detecting AF. However, there is still limited knowledge about the applicability of the PPG solutions in free-living conditions. The aim of this study was to compare the inter-beat interval derived features for AF detection between ECG and wrist-worn PPG in daily life.

APPROACH: The data consisted of 24 h ECG, PPG, and accelerometer measurements from 27 patients (eight AF, 19 non-AF). In total, seven features (Shannon entropy, root mean square of successive differences (RMSSD), normalized RMSSD, pNN40, pNN70, sample entropy, and coefficient of sample entropy (CosEn)) were compared. Body movement was measured with the accelerometer and used with three different thresholds to exclude PPG segments affected by movement.

MAIN RESULTS: CosEn resulted as the best performing feature from ECG with Cohens kappa 0.95. When the strictest movement threshold was applied, the same performance was obtained with PPG (kappa  =  0.96). In addition, pNN40 and pNN70 reached similar results with the same threshold (kappa  =  0.95 and 0.94), but were more robust with respect to movement artefacts. The coverage of PPG was 24.0%-57.6% depending on the movement threshold compared to 92.1% of ECG.

SIGNIFICANCE: The inter-beat interval features derived from PPG are equivalent to the ones from ECG for AF detection. Movement artefacts substantially worsen PPG-based AF monitoring in free-living conditions, therefore monitoring coverage needs to be carefully selected. Wrist-worn PPG still provides a promising technology for long-term AF monitoring.

Original languageEnglish
Article number084001
JournalPhysiological Measurement
Volume39
Issue number8
DOIs
Publication statusPublished - 8 Aug 2018

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Photoplethysmography
Social Conditions
Electrocardiography
Atrial Fibrillation
Entropy
Monitoring
Wrist
Accelerometers
Artifacts
Asymptomatic Diseases
Condition monitoring
Cardiac Arrhythmias
Heart Failure
Heart Rate
Stroke

Cite this

@article{c3d6ee1b51924a298729e8205f9a1df6,
title = "Comparison between electrocardiogram- and photoplethysmogram-derived features for atrial fibrillation detection in free-living conditions",
abstract = "OBJECTIVE: Atrial fibrillation (AF) is the most commonly experienced arrhythmia and it increases the risk of stroke and heart failure. The challenge in detecting the presence of AF is the occasional and asymptomatic manifestation of the condition. Long-term monitoring can increase the sensitivity of detecting intermittent AF episodes, however it is either cumbersome or invasive and costly with electrocardiography (ECG). Photoplethysmography (PPG) is an unobtrusive measuring modality enabling heart rate monitoring, and promising results have been presented in detecting AF. However, there is still limited knowledge about the applicability of the PPG solutions in free-living conditions. The aim of this study was to compare the inter-beat interval derived features for AF detection between ECG and wrist-worn PPG in daily life.APPROACH: The data consisted of 24 h ECG, PPG, and accelerometer measurements from 27 patients (eight AF, 19 non-AF). In total, seven features (Shannon entropy, root mean square of successive differences (RMSSD), normalized RMSSD, pNN40, pNN70, sample entropy, and coefficient of sample entropy (CosEn)) were compared. Body movement was measured with the accelerometer and used with three different thresholds to exclude PPG segments affected by movement.MAIN RESULTS: CosEn resulted as the best performing feature from ECG with Cohens kappa 0.95. When the strictest movement threshold was applied, the same performance was obtained with PPG (kappa  =  0.96). In addition, pNN40 and pNN70 reached similar results with the same threshold (kappa  =  0.95 and 0.94), but were more robust with respect to movement artefacts. The coverage of PPG was 24.0{\%}-57.6{\%} depending on the movement threshold compared to 92.1{\%} of ECG.SIGNIFICANCE: The inter-beat interval features derived from PPG are equivalent to the ones from ECG for AF detection. Movement artefacts substantially worsen PPG-based AF monitoring in free-living conditions, therefore monitoring coverage needs to be carefully selected. Wrist-worn PPG still provides a promising technology for long-term AF monitoring.",
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Comparison between electrocardiogram- and photoplethysmogram-derived features for atrial fibrillation detection in free-living conditions. / Eerikäinen, Linda M.; Bonomi, Alberto G.; Schipper, Fons; Dekker, Lukas R.C.; Vullings, Rik; de Morree, Helma M.; Aarts, Ronald M.

In: Physiological Measurement, Vol. 39, No. 8, 084001, 08.08.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Comparison between electrocardiogram- and photoplethysmogram-derived features for atrial fibrillation detection in free-living conditions

AU - Eerikäinen, Linda M.

AU - Bonomi, Alberto G.

AU - Schipper, Fons

AU - Dekker, Lukas R.C.

AU - Vullings, Rik

AU - de Morree, Helma M.

AU - Aarts, Ronald M.

PY - 2018/8/8

Y1 - 2018/8/8

N2 - OBJECTIVE: Atrial fibrillation (AF) is the most commonly experienced arrhythmia and it increases the risk of stroke and heart failure. The challenge in detecting the presence of AF is the occasional and asymptomatic manifestation of the condition. Long-term monitoring can increase the sensitivity of detecting intermittent AF episodes, however it is either cumbersome or invasive and costly with electrocardiography (ECG). Photoplethysmography (PPG) is an unobtrusive measuring modality enabling heart rate monitoring, and promising results have been presented in detecting AF. However, there is still limited knowledge about the applicability of the PPG solutions in free-living conditions. The aim of this study was to compare the inter-beat interval derived features for AF detection between ECG and wrist-worn PPG in daily life.APPROACH: The data consisted of 24 h ECG, PPG, and accelerometer measurements from 27 patients (eight AF, 19 non-AF). In total, seven features (Shannon entropy, root mean square of successive differences (RMSSD), normalized RMSSD, pNN40, pNN70, sample entropy, and coefficient of sample entropy (CosEn)) were compared. Body movement was measured with the accelerometer and used with three different thresholds to exclude PPG segments affected by movement.MAIN RESULTS: CosEn resulted as the best performing feature from ECG with Cohens kappa 0.95. When the strictest movement threshold was applied, the same performance was obtained with PPG (kappa  =  0.96). In addition, pNN40 and pNN70 reached similar results with the same threshold (kappa  =  0.95 and 0.94), but were more robust with respect to movement artefacts. The coverage of PPG was 24.0%-57.6% depending on the movement threshold compared to 92.1% of ECG.SIGNIFICANCE: The inter-beat interval features derived from PPG are equivalent to the ones from ECG for AF detection. Movement artefacts substantially worsen PPG-based AF monitoring in free-living conditions, therefore monitoring coverage needs to be carefully selected. Wrist-worn PPG still provides a promising technology for long-term AF monitoring.

AB - OBJECTIVE: Atrial fibrillation (AF) is the most commonly experienced arrhythmia and it increases the risk of stroke and heart failure. The challenge in detecting the presence of AF is the occasional and asymptomatic manifestation of the condition. Long-term monitoring can increase the sensitivity of detecting intermittent AF episodes, however it is either cumbersome or invasive and costly with electrocardiography (ECG). Photoplethysmography (PPG) is an unobtrusive measuring modality enabling heart rate monitoring, and promising results have been presented in detecting AF. However, there is still limited knowledge about the applicability of the PPG solutions in free-living conditions. The aim of this study was to compare the inter-beat interval derived features for AF detection between ECG and wrist-worn PPG in daily life.APPROACH: The data consisted of 24 h ECG, PPG, and accelerometer measurements from 27 patients (eight AF, 19 non-AF). In total, seven features (Shannon entropy, root mean square of successive differences (RMSSD), normalized RMSSD, pNN40, pNN70, sample entropy, and coefficient of sample entropy (CosEn)) were compared. Body movement was measured with the accelerometer and used with three different thresholds to exclude PPG segments affected by movement.MAIN RESULTS: CosEn resulted as the best performing feature from ECG with Cohens kappa 0.95. When the strictest movement threshold was applied, the same performance was obtained with PPG (kappa  =  0.96). In addition, pNN40 and pNN70 reached similar results with the same threshold (kappa  =  0.95 and 0.94), but were more robust with respect to movement artefacts. The coverage of PPG was 24.0%-57.6% depending on the movement threshold compared to 92.1% of ECG.SIGNIFICANCE: The inter-beat interval features derived from PPG are equivalent to the ones from ECG for AF detection. Movement artefacts substantially worsen PPG-based AF monitoring in free-living conditions, therefore monitoring coverage needs to be carefully selected. Wrist-worn PPG still provides a promising technology for long-term AF monitoring.

U2 - 10.1088/1361-6579/aad2c0

DO - 10.1088/1361-6579/aad2c0

M3 - Article

C2 - 29995641

VL - 39

JO - Physiological Measurement

JF - Physiological Measurement

SN - 0967-3334

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M1 - 084001

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