Comparing signal-to-noise ratio for prostate imaging at 7T and 3T

Bart R. Steensma (Corresponding author), Mariska Luttje, Ingmar J. Voogt, Dennis W.J. Klomp, Peter R. Luijten, Cornelis A.T. van den Berg, Alexander J.E. Raaijmakers

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Abstract

Background: In MRI, the signal-to-noise ratio (SNR) theoretically increases with B 0 field strength. However, because of attenuation of the radiofrequency (RF) fields at 7T, it is not certain if this SNR gain can be realized for prostate imaging. Purpose/Hypothesis: To investigate the SNR gain in prostate imaging at 7T as compared with 3T. It is expected that SNR will improve for prostate imaging at 7T compared with 3T. Study Type: Prospective. Subjects: Four healthy volunteers and one prostate cancer patient. Field Strength/Sequence: All subjects were scanned at 3T and at 7T using optimal coil setups for both field strengths. For all volunteers, proton density-weighted images were acquired for SNR analysis and actual flip angle imaging (AFI) B 1 +| maps were acquired for correction of measured SNR values. In the patient, a T 2 -weighted (T 2 w) image was acquired at 3T and at 7T. Assessment: SNR was calculated in the prostate region for all volunteers. SNR was normalized for flip angle, receiver bandwidth, and voxel volume. SNR was also calculated for different sensitivity encoding (SENSE) acceleration factors. Statistical Testing: SNR values are represented as the arithmetic mean of SNR values in the prostate. Estimated SNR in the T 2 w image is calculated as the arithmetic mean of the signal intensity (SI) divided by the standard deviation of the SI in a specified zone. Tumor-to-tissue contrast is calculated as (SI tumor +SI zone )/(SI tumor -SI zone ). Results: An increase in SNR ranging from 1.7-fold to 2.8-fold was measured in the prostate at 7T in comparison to 3T for four volunteers. At 7T, it is possible to achieve a 4-fold SENSE acceleration in the left-right direction with similar SNR to a nonaccelerated 3T image. T 2 w imaging was done at 3T and 7T in one patient, where improved tumor-to-tissue contrast was demonstrated at 7T. Data Conclusion: SNR improves for prostate imaging at 7T as compared with 3T. Level of Evidence: 2. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2019;49:1446–1455.

Original languageEnglish
Pages (from-to)1446-1455
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume49
Issue number5
DOIs
Publication statusPublished - May 2019

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Signal-To-Noise Ratio
Prostate
Volunteers
Neoplasms
Protons
Prostatic Neoplasms
Healthy Volunteers

Keywords

  • 3T
  • 7T
  • prostate cancer
  • SNR

Cite this

Steensma, B. R., Luttje, M., Voogt, I. J., Klomp, D. W. J., Luijten, P. R., van den Berg, C. A. T., & Raaijmakers, A. J. E. (2019). Comparing signal-to-noise ratio for prostate imaging at 7T and 3T. Journal of Magnetic Resonance Imaging, 49(5), 1446-1455. https://doi.org/10.1002/jmri.26527
Steensma, Bart R. ; Luttje, Mariska ; Voogt, Ingmar J. ; Klomp, Dennis W.J. ; Luijten, Peter R. ; van den Berg, Cornelis A.T. ; Raaijmakers, Alexander J.E. / Comparing signal-to-noise ratio for prostate imaging at 7T and 3T. In: Journal of Magnetic Resonance Imaging. 2019 ; Vol. 49, No. 5. pp. 1446-1455.
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Steensma, BR, Luttje, M, Voogt, IJ, Klomp, DWJ, Luijten, PR, van den Berg, CAT & Raaijmakers, AJE 2019, 'Comparing signal-to-noise ratio for prostate imaging at 7T and 3T', Journal of Magnetic Resonance Imaging, vol. 49, no. 5, pp. 1446-1455. https://doi.org/10.1002/jmri.26527

Comparing signal-to-noise ratio for prostate imaging at 7T and 3T. / Steensma, Bart R. (Corresponding author); Luttje, Mariska; Voogt, Ingmar J.; Klomp, Dennis W.J.; Luijten, Peter R.; van den Berg, Cornelis A.T.; Raaijmakers, Alexander J.E.

In: Journal of Magnetic Resonance Imaging, Vol. 49, No. 5, 05.2019, p. 1446-1455.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Luttje, Mariska

AU - Voogt, Ingmar J.

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AU - Luijten, Peter R.

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N2 - Background: In MRI, the signal-to-noise ratio (SNR) theoretically increases with B 0 field strength. However, because of attenuation of the radiofrequency (RF) fields at 7T, it is not certain if this SNR gain can be realized for prostate imaging. Purpose/Hypothesis: To investigate the SNR gain in prostate imaging at 7T as compared with 3T. It is expected that SNR will improve for prostate imaging at 7T compared with 3T. Study Type: Prospective. Subjects: Four healthy volunteers and one prostate cancer patient. Field Strength/Sequence: All subjects were scanned at 3T and at 7T using optimal coil setups for both field strengths. For all volunteers, proton density-weighted images were acquired for SNR analysis and actual flip angle imaging (AFI) B 1 +| maps were acquired for correction of measured SNR values. In the patient, a T 2 -weighted (T 2 w) image was acquired at 3T and at 7T. Assessment: SNR was calculated in the prostate region for all volunteers. SNR was normalized for flip angle, receiver bandwidth, and voxel volume. SNR was also calculated for different sensitivity encoding (SENSE) acceleration factors. Statistical Testing: SNR values are represented as the arithmetic mean of SNR values in the prostate. Estimated SNR in the T 2 w image is calculated as the arithmetic mean of the signal intensity (SI) divided by the standard deviation of the SI in a specified zone. Tumor-to-tissue contrast is calculated as (SI tumor +SI zone )/(SI tumor -SI zone ). Results: An increase in SNR ranging from 1.7-fold to 2.8-fold was measured in the prostate at 7T in comparison to 3T for four volunteers. At 7T, it is possible to achieve a 4-fold SENSE acceleration in the left-right direction with similar SNR to a nonaccelerated 3T image. T 2 w imaging was done at 3T and 7T in one patient, where improved tumor-to-tissue contrast was demonstrated at 7T. Data Conclusion: SNR improves for prostate imaging at 7T as compared with 3T. Level of Evidence: 2. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2019;49:1446–1455.

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Steensma BR, Luttje M, Voogt IJ, Klomp DWJ, Luijten PR, van den Berg CAT et al. Comparing signal-to-noise ratio for prostate imaging at 7T and 3T. Journal of Magnetic Resonance Imaging. 2019 May;49(5):1446-1455. https://doi.org/10.1002/jmri.26527