Combinatorial functionalization with bisurea-peptides and antifouling bisurea additives of a supramolecular elastomeric biomaterial

Bastiaan D. Ippel, Boris Arts, Henk Keizer, Patricia Y.W. Dankers (Corresponding author)

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Abstract

The bioactive additive toolbox to functionalize supramolecular elastomeric materials expands rapidly. Here we have set an explorative step toward screening of complex combinatorial functionalization with antifouling and three peptide-containing additives in a bisurea-based supramolecular system. Thorough investigation of surface properties of thin films with contact angle measurements, X-ray photoelectron spectroscopy and atomic force microscopy, was correlated to cell-adhesion of endothelial and smooth muscle cells to apprehend their respective predictive values for functional biomaterial development. Peptides were presented at the surface alone, and in combinatorial functionalization with the oligo(ethylene glycol)-based non-cell adhesive additive. The bisurea-RGD additive was cell-adhesive in all conditions, whereas the endothelial cell-specific bisurea-REDV showed limited bioactive properties in all chemical nano-environments. Also, aspecific functionality was observed for a bisurea-SDF1α peptide. These results emphasize that special care should be taken in changing the chemical nano-environment with peptide functionalization.

Original languageEnglish
Pages (from-to)1725-1735
Number of pages11
JournalJournal of Polymer Science, Part B: Polymer Physics
Volume57
Issue number24
Early online date2019
DOIs
Publication statusPublished - 15 Dec 2019

Keywords

  • additives
  • biointerfaces
  • peptides
  • screening
  • supramolecular biomaterials

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