Column liquid chromotography of tricyclic antidepressants

J.H.M. van den Berg; H.J.J.M. de Ruwe; R.S. Deelder; Th.A. Plomp

doi:10.1016/S0021-9673(00)94978-1

Column liquid chromotography of tricyclic antidepressants

J.H.M. van den Berg, H.J.J.M. de Ruwe, R.S. Deelder, Th.A. Plomp

Chemical Engineering and Chemistry

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Abstract

A column liquid chromatographic system for the analysis of tricyclic antidepressants in serum is described. A high separation efficiency can be obtained with a mixture of ethyl acetate, n-hexane and methylamine as eluent on a silica gel column. The retention is easily regulated by varying the concentration of n-hexane, the modifier methylamine and the water content of the ethyl acetate. Examples are given of separations of test mixtures of tricyclic antidepressants and of some of these drugs in serum. UV detection permits determinations down to the 10-ng level in serum.

Original language	English
Pages (from-to)	431-436
Journal	Journal of Chromatography
Volume	138
Issue number	2
DOIs	https://doi.org/10.1016/S0021-9673(00)94978-1
Publication status	Published - 1977

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title = "Column liquid chromotography of tricyclic antidepressants",

abstract = "A column liquid chromatographic system for the analysis of tricyclic antidepressants in serum is described. A high separation efficiency can be obtained with a mixture of ethyl acetate, n-hexane and methylamine as eluent on a silica gel column. The retention is easily regulated by varying the concentration of n-hexane, the modifier methylamine and the water content of the ethyl acetate. Examples are given of separations of test mixtures of tricyclic antidepressants and of some of these drugs in serum. UV detection permits determinations down to the 10-ng level in serum.",

author = "{van den Berg}, J.H.M. and {de Ruwe}, H.J.J.M. and R.S. Deelder and Th.A. Plomp",

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T1 - Column liquid chromotography of tricyclic antidepressants

AU - van den Berg, J.H.M.

AU - de Ruwe, H.J.J.M.

AU - Deelder, R.S.

AU - Plomp, Th.A.

PY - 1977

Y1 - 1977

N2 - A column liquid chromatographic system for the analysis of tricyclic antidepressants in serum is described. A high separation efficiency can be obtained with a mixture of ethyl acetate, n-hexane and methylamine as eluent on a silica gel column. The retention is easily regulated by varying the concentration of n-hexane, the modifier methylamine and the water content of the ethyl acetate. Examples are given of separations of test mixtures of tricyclic antidepressants and of some of these drugs in serum. UV detection permits determinations down to the 10-ng level in serum.

AB - A column liquid chromatographic system for the analysis of tricyclic antidepressants in serum is described. A high separation efficiency can be obtained with a mixture of ethyl acetate, n-hexane and methylamine as eluent on a silica gel column. The retention is easily regulated by varying the concentration of n-hexane, the modifier methylamine and the water content of the ethyl acetate. Examples are given of separations of test mixtures of tricyclic antidepressants and of some of these drugs in serum. UV detection permits determinations down to the 10-ng level in serum.

U2 - 10.1016/S0021-9673(00)94978-1

DO - 10.1016/S0021-9673(00)94978-1

M3 - Article

SN - 0021-9673

VL - 138

SP - 431

EP - 436

JO - Journal of Chromatography

JF - Journal of Chromatography

IS - 2

ER -

Column liquid chromotography of tricyclic antidepressants

Abstract

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