Cognitive development in absence epilepsy during long-term follow-up

Eric L.A. Fonseca Wald, Sylvia Klinkenberg, Twan P.C. Voncken, Saskia C.M. Ebus, Albert P. Aldenkamp, Johan S.H. Vles, R. Jeroen Vermeulen, Jos G.M. Hendriksen, Mariette H.J.A. Debeij-van Hall (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Absence epilepsy (AE) has been associated with lower than average cognitive functioning, which are clinically relevant in some and may predispose to problems later in life. This study aimed to assess cognitive development during long-term follow-up in children with AE. Thirty-one children with AE, who had undergone two neuropsychological assessments between 2010 and 2017 were analyzed retrospectively. Cognitive measurements were 1.7 ± 0.95 years apart. The difference in neurocognitive test scores was assessed on a group level and on an individual level using reliable change methodology. Results show that sustained attention was lower at the first measurement compared to the normative mean. Sustained attention improved during follow-up and 7 out of 14 children showed improvement after correction for practice effects. Receptive vocabulary showed a decline over time, but did not differ from the normative mean. Significant lower mean group scores were present for performance IQ, perceptual organization, processing speed, simple reaction times, and visual motor integration, while being stable over time in the majority of children. Cognitive development was not associated with seizure freedom. Mild-to-severe academic underachievement was present in 65% and comorbidities that might affect learning in 38%. This study in children with AE showed improvement in sustained attention during long-term follow-up while other cognitive weaknesses persisted over time, regardless of seizure freedom.

LanguageEnglish
Pages1003-1021
JournalChild Neuropsychology
Volume25
Issue number8
DOIs
StatePublished - 2019

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Absence Epilepsy
Seizures
Underachievement
Vocabulary
Reaction Time
Comorbidity
Learning

Keywords

  • Absence epilepsy
  • academic performance
  • cognition
  • longitudinal
  • neurodevelopment

Cite this

Fonseca Wald, E. L. A., Klinkenberg, S., Voncken, T. P. C., Ebus, S. C. M., Aldenkamp, A. P., Vles, J. S. H., ... Debeij-van Hall, M. H. J. A. (2019). Cognitive development in absence epilepsy during long-term follow-up. Child Neuropsychology, 25(8), 1003-1021. DOI: 10.1080/09297049.2019.1614156
Fonseca Wald, Eric L.A. ; Klinkenberg, Sylvia ; Voncken, Twan P.C. ; Ebus, Saskia C.M. ; Aldenkamp, Albert P. ; Vles, Johan S.H. ; Vermeulen, R. Jeroen ; Hendriksen, Jos G.M. ; Debeij-van Hall, Mariette H.J.A./ Cognitive development in absence epilepsy during long-term follow-up. In: Child Neuropsychology. 2019 ; Vol. 25, No. 8. pp. 1003-1021
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abstract = "Absence epilepsy (AE) has been associated with lower than average cognitive functioning, which are clinically relevant in some and may predispose to problems later in life. This study aimed to assess cognitive development during long-term follow-up in children with AE. Thirty-one children with AE, who had undergone two neuropsychological assessments between 2010 and 2017 were analyzed retrospectively. Cognitive measurements were 1.7 ± 0.95 years apart. The difference in neurocognitive test scores was assessed on a group level and on an individual level using reliable change methodology. Results show that sustained attention was lower at the first measurement compared to the normative mean. Sustained attention improved during follow-up and 7 out of 14 children showed improvement after correction for practice effects. Receptive vocabulary showed a decline over time, but did not differ from the normative mean. Significant lower mean group scores were present for performance IQ, perceptual organization, processing speed, simple reaction times, and visual motor integration, while being stable over time in the majority of children. Cognitive development was not associated with seizure freedom. Mild-to-severe academic underachievement was present in 65{\%} and comorbidities that might affect learning in 38{\%}. This study in children with AE showed improvement in sustained attention during long-term follow-up while other cognitive weaknesses persisted over time, regardless of seizure freedom.",
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Fonseca Wald, ELA, Klinkenberg, S, Voncken, TPC, Ebus, SCM, Aldenkamp, AP, Vles, JSH, Vermeulen, RJ, Hendriksen, JGM & Debeij-van Hall, MHJA 2019, 'Cognitive development in absence epilepsy during long-term follow-up' Child Neuropsychology, vol. 25, no. 8, pp. 1003-1021. DOI: 10.1080/09297049.2019.1614156

Cognitive development in absence epilepsy during long-term follow-up. / Fonseca Wald, Eric L.A.; Klinkenberg, Sylvia; Voncken, Twan P.C.; Ebus, Saskia C.M.; Aldenkamp, Albert P.; Vles, Johan S.H.; Vermeulen, R. Jeroen; Hendriksen, Jos G.M.; Debeij-van Hall, Mariette H.J.A. (Corresponding author).

In: Child Neuropsychology, Vol. 25, No. 8, 2019, p. 1003-1021.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Fonseca Wald,Eric L.A.

AU - Klinkenberg,Sylvia

AU - Voncken,Twan P.C.

AU - Ebus,Saskia C.M.

AU - Aldenkamp,Albert P.

AU - Vles,Johan S.H.

AU - Vermeulen,R. Jeroen

AU - Hendriksen,Jos G.M.

AU - Debeij-van Hall,Mariette H.J.A.

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Fonseca Wald ELA, Klinkenberg S, Voncken TPC, Ebus SCM, Aldenkamp AP, Vles JSH et al. Cognitive development in absence epilepsy during long-term follow-up. Child Neuropsychology. 2019;25(8):1003-1021. Available from, DOI: 10.1080/09297049.2019.1614156