Integrated performance simulation of buildings' heating, ventilation and air-conditioning (HVAC) systems can help in reducing energy consumption and increasing occupant comfort. However, no single building performance simulation (BPS) tool offers sufficient capabilities and flexibilities to analyse integrated building systems and to enable rapid prototyping of innovative building and system technologies. One way to alleviate this problem is to use co-simulation, as an integrated approach to simulation. This article elaborates on issues important for co-simulation realization and discusses multiple possibilities to justify the particular approach implemented in the here described co-simulation prototype. The prototype is validated with the results obtained from the traditional simulation approach. It is further used in a proof-of-concept case study to demonstrate the applicability of the method and to highlight its benefits. Stability and accuracy of different coupling strategies are analysed to give a guideline for the required coupling time step.