Clusters in short-term disease course in participants with primary dupuytren disease

R. Lanting, E.R. Van Den Heuvel, P.M.N. Werker

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)


Purpose The course of Dupuytren disease (DD) is thought to be progressive; however, the course differs for each patient. The purpose of this study was to study the rate and pattern of progression of DD. Methods We prospectively analyzed the course of DD at intervals of 3 to 6 months in 247 Dutch participants with primary DD by measuring the surface area of nodules and cords and the total passive extension deficit. The association between surface area and Tubiana stage was tested with generalized estimating equations. Latent class models were used to study different clusters in changes regarding the course of the disease. Results The variance in disease course between participants was large. Regarding the change in surface area (in all fingers) and total passive extension deficit (in the ring and little finger), different clusters were observed. Progression of disease was seen but there were also signs of stability and even regression. Patients with a smaller surface area at baseline were more likely to exhibit regression. Conclusions This study showed that DD is not always progressive and that up to 75% of patients have a different short-term disease course, such as stability or even regression of disease. This should be taken into account when evaluating the effects of treatment for early-phase DD and in the design of future studies. Furthermore, this information may be useful when counseling patients. Type of study/level of evidence Prognostic II.

Original languageEnglish
Pages (from-to)354-361
Number of pages8
JournalJournal of Hand Surgery
Issue number3
Publication statusPublished - 1 Mar 2016


  • Disease course
  • disease progression
  • disease regression
  • Dupuytren contracture
  • Dupuytren disease


Dive into the research topics of 'Clusters in short-term disease course in participants with primary dupuytren disease'. Together they form a unique fingerprint.

Cite this