Click chemistry beyond metal-catalyzed cycloaddition

C.R. Becer, R. Hoogenboom, U.S. Schubert

Research output: Contribution to journalArticleAcademicpeer-review

769 Citations (Scopus)


The overwhelming success of click chemistry encouraged researchers to develop alternative "spring-loaded" chemical reactions for use in different fields of chemistry. Initially, the copper(I)-catalyzed azidealkyne cycloaddition was the only click reaction. In recent years, metal-free [3+2] cycloaddition reactions, Diels-Alder reactions, and thiol-alkene radical addition reactions have come to the fore as click reactions because of their simple synthetic procedures and high yields. Furthermore, these metal-free reactions have wide applicability and are physiologically compatible. These and other alternative click reactions expand the opportunities for synthesizing small organic compounds as well as tailor-made macromolecules and bioconjugates. This Minireview discusses the success and applicability of new, in particular metal-free, click reactions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Original languageEnglish
Pages (from-to)4900-4908
JournalAngewandte Chemie - International Edition
Issue number27
Publication statusPublished - 2009


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