The overwhelming success of click chemistry encouraged researchers to develop alternative "spring-loaded" chemical reactions for use in different fields of chemistry. Initially, the copper(I)-catalyzed azidealkyne cycloaddition was the only click reaction. In recent years, metal-free [3+2] cycloaddition reactions, Diels-Alder reactions, and thiol-alkene radical addition reactions have come to the fore as click reactions because of their simple synthetic procedures and high yields. Furthermore, these metal-free reactions have wide applicability and are physiologically compatible. These and other alternative click reactions expand the opportunities for synthesizing small organic compounds as well as tailor-made macromolecules and bioconjugates. This Minireview discusses the success and applicability of new, in particular metal-free, click reactions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Becer, C. R., Hoogenboom, R., & Schubert, U. S. (2009). Click chemistry beyond metal-catalyzed cycloaddition. Angewandte Chemie - International Edition, 48(27), 4900-4908. https://doi.org/10.1002/anie.200900755