Circulating tumor cell isolation and diagnostics: toward routine clinical use

A. Stolpe, van de, K. Pantel, S. Sleijfer, L.W. Terstappen, J.M.J. Toonder, den

Research output: Contribution to journalArticleAcademicpeer-review

167 Citations (Scopus)


From February 7–11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held in Leiden (The Netherlands) to discuss progress and define challenges and potential solutions for development of clinically useful circulating tumor cell (CTC) diagnostics. CTCs, captured as "liquid biopsy" from blood, for counting and characterization using pathology and molecular assays, are expected to replace metastatic tissue biopsies to be used to predict drug response and resistance and to monitor therapy response and cancer recurrence. CTCs are highly heterogeneous; therefore, cancer type–specific isolation technologies, as well as complex clinical interpretation software, are required. Cancer Res; 71(18); 5955–60. ©2011 AACR.
Original languageEnglish
Pages (from-to)5955-5960
JournalCancer Research
Issue number18
Publication statusPublished - 13 Sept 2011


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