Chronic antiepileptic drug use and functional network efficiency: a functional magnetic resonance imaging study

T.M. van Veenendaal, D.M. IJff, A.P. Aldenkamp, R.H.C. Lazeron, P.A.M. Hofman, A.J.A. de Louw, W.H. Backes, J.F.A. Jansen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

AIM: To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug (AED) treatment.

METHODS: The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A "low risk" category (lamotrigine or levetiracetam, n = 16), an "intermediate risk" category (carbamazepine, oxcarbazepine, phenytoin, or valproate, n = 34) and a "high risk" category (topiramate, n = 5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment.

RESULTS: Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant (P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category (P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient (ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient (linear regression analysis, P > 0.15) were observed.

CONCLUSION: Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects.

LanguageEnglish
Pages287-294
Number of pages8
JournalWorld Journal of Radiology
Volume9
Issue number6
DOIs
StatePublished - 28 Jun 2017

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Anticonvulsants
Magnetic Resonance Imaging
Automatic Data Processing
etiracetam
Drug-Related Side Effects and Adverse Reactions
Cluster Analysis
Brain
Carbamazepine
Valproic Acid
Phenytoin
Cognition
Linear Models
Epilepsy
Magnetic Resonance Spectroscopy
Regression Analysis
Therapeutics

Keywords

  • Journal Article

Cite this

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title = "Chronic antiepileptic drug use and functional network efficiency: a functional magnetic resonance imaging study",
abstract = "AIM: To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug (AED) treatment.METHODS: The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A {"}low risk{"} category (lamotrigine or levetiracetam, n = 16), an {"}intermediate risk{"} category (carbamazepine, oxcarbazepine, phenytoin, or valproate, n = 34) and a {"}high risk{"} category (topiramate, n = 5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment.RESULTS: Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant (P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category (P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient (ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient (linear regression analysis, P > 0.15) were observed.CONCLUSION: Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects.",
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author = "{van Veenendaal}, T.M. and D.M. IJff and A.P. Aldenkamp and R.H.C. Lazeron and P.A.M. Hofman and {de Louw}, A.J.A. and W.H. Backes and J.F.A. Jansen",
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Chronic antiepileptic drug use and functional network efficiency : a functional magnetic resonance imaging study. / van Veenendaal, T.M.; IJff, D.M.; Aldenkamp, A.P.; Lazeron, R.H.C.; Hofman, P.A.M.; de Louw, A.J.A.; Backes, W.H.; Jansen, J.F.A.

In: World Journal of Radiology, Vol. 9, No. 6, 28.06.2017, p. 287-294.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Chronic antiepileptic drug use and functional network efficiency

T2 - World Journal of Radiology

AU - van Veenendaal,T.M.

AU - IJff,D.M.

AU - Aldenkamp,A.P.

AU - Lazeron,R.H.C.

AU - Hofman,P.A.M.

AU - de Louw,A.J.A.

AU - Backes,W.H.

AU - Jansen,J.F.A.

PY - 2017/6/28

Y1 - 2017/6/28

N2 - AIM: To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug (AED) treatment.METHODS: The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A "low risk" category (lamotrigine or levetiracetam, n = 16), an "intermediate risk" category (carbamazepine, oxcarbazepine, phenytoin, or valproate, n = 34) and a "high risk" category (topiramate, n = 5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment.RESULTS: Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant (P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category (P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient (ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient (linear regression analysis, P > 0.15) were observed.CONCLUSION: Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects.

AB - AIM: To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug (AED) treatment.METHODS: The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A "low risk" category (lamotrigine or levetiracetam, n = 16), an "intermediate risk" category (carbamazepine, oxcarbazepine, phenytoin, or valproate, n = 34) and a "high risk" category (topiramate, n = 5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment.RESULTS: Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant (P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category (P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient (ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient (linear regression analysis, P > 0.15) were observed.CONCLUSION: Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects.

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