Abstract
Two peptide-derived low-molecular-weight gelators bearing different capping groups, 9-fluorenylmethyloxycarbonyl (Fmoc) and phenothiazine, were synthesized and their gel networks were characterized. The variation of the N-terminal capping group affects the viability of these hydrogels as a three-dimensional cell culture for multicellular tumor spheroids. These results indicate that the phenothiazine capping group is a more biocompatible alternative to the widely used Fmoc moiety.
Original language | English |
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Pages (from-to) | 383-389 |
Number of pages | 7 |
Journal | ChemPlusChem |
Volume | 82 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Mar 2017 |
Externally published | Yes |
Keywords
- cytotoxicity
- gels
- peptides
- self-assembly
- tumor spheroids