Choice of capping group in tripeptide hydrogels influences viability in the three-dimensional cell culture of tumor spheroids

Jonathan P. Wojciechowski, Adam D. Martin, Alexander F. Mason, Christopher M. Fife, Sharon M. Sagnella, Maria Kavallaris, Pall Thordarson

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

Two peptide-derived low-molecular-weight gelators bearing different capping groups, 9-fluorenylmethyloxycarbonyl (Fmoc) and phenothiazine, were synthesized and their gel networks were characterized. The variation of the N-terminal capping group affects the viability of these hydrogels as a three-dimensional cell culture for multicellular tumor spheroids. These results indicate that the phenothiazine capping group is a more biocompatible alternative to the widely used Fmoc moiety.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
Journalchempluschem
Volume82
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

Keywords

  • cytotoxicity
  • gels
  • peptides
  • self-assembly
  • tumor spheroids

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