Chiral synthetic analogs of myosin

H.M. Janssen; M.H.P. Genderen, van; E.W. Meijer

Chiral synthetic analogs of myosin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

Abstract

Synthetic analogs of coiled-coil forming peptides are presented. These analogs are based on modified polyethylene oxides and have a repeat of polar ethylene glycol or 2-oxo ethylene glycol segments (P) and apolar (S)-2-alkyl-substituted ethylene glycol segments (A). Polymers of the type [PAPPAPP]n and [PPAP]n were prepd. by SnOct2-catalyzed polymn. of (S),(S)-8, 17-diisobutyl-2-oxo-21-crown-7 and (S)-5-alkyl-2-oxo-12-crown-4 monomers. The assocn. of these polymers in soln. was analyzed by ORD-measurements, revealing an inversion of main-chain chirality induced by increasing the polarity of the solvent. [on SciFinder (R)]

Original language	English
Title of host publication	Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29
Place of Publication	Orlando, FL
Publisher	American Chemical Society
Pages	ORGN-313
Publication status	Published - 1996
Event	212th ACS National Meeting - Orlando, United States Duration: 25 Aug 1996 → 29 Aug 1996

Conference

Conference	212th ACS National Meeting
Country/Territory	United States
City	Orlando
Period	25/08/96 → 29/08/96

Cite this

@inproceedings{a56f65f0dbf34338a087f79ab850de06,

title = "Chiral synthetic analogs of myosin",

abstract = "Synthetic analogs of coiled-coil forming peptides are presented. These analogs are based on modified polyethylene oxides and have a repeat of polar ethylene glycol or 2-oxo ethylene glycol segments (P) and apolar (S)-2-alkyl-substituted ethylene glycol segments (A). Polymers of the type [PAPPAPP]n and [PPAP]n were prepd. by SnOct2-catalyzed polymn. of (S),(S)-8, 17-diisobutyl-2-oxo-21-crown-7 and (S)-5-alkyl-2-oxo-12-crown-4 monomers. The assocn. of these polymers in soln. was analyzed by ORD-measurements, revealing an inversion of main-chain chirality induced by increasing the polarity of the solvent. [on SciFinder (R)]",

author = "H.M. Janssen and \{Genderen, van\}, M.H.P. and E.W. Meijer",

year = "1996",

language = "English",

pages = "ORGN--313",

booktitle = "Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29",

publisher = "American Chemical Society",

address = "United States",

note = "212th ACS National Meeting ; Conference date: 25-08-1996 Through 29-08-1996",

}

TY - GEN

T1 - Chiral synthetic analogs of myosin

AU - Janssen, H.M.

AU - Genderen, van, M.H.P.

AU - Meijer, E.W.

PY - 1996

Y1 - 1996

N2 - Synthetic analogs of coiled-coil forming peptides are presented. These analogs are based on modified polyethylene oxides and have a repeat of polar ethylene glycol or 2-oxo ethylene glycol segments (P) and apolar (S)-2-alkyl-substituted ethylene glycol segments (A). Polymers of the type [PAPPAPP]n and [PPAP]n were prepd. by SnOct2-catalyzed polymn. of (S),(S)-8, 17-diisobutyl-2-oxo-21-crown-7 and (S)-5-alkyl-2-oxo-12-crown-4 monomers. The assocn. of these polymers in soln. was analyzed by ORD-measurements, revealing an inversion of main-chain chirality induced by increasing the polarity of the solvent. [on SciFinder (R)]

AB - Synthetic analogs of coiled-coil forming peptides are presented. These analogs are based on modified polyethylene oxides and have a repeat of polar ethylene glycol or 2-oxo ethylene glycol segments (P) and apolar (S)-2-alkyl-substituted ethylene glycol segments (A). Polymers of the type [PAPPAPP]n and [PPAP]n were prepd. by SnOct2-catalyzed polymn. of (S),(S)-8, 17-diisobutyl-2-oxo-21-crown-7 and (S)-5-alkyl-2-oxo-12-crown-4 monomers. The assocn. of these polymers in soln. was analyzed by ORD-measurements, revealing an inversion of main-chain chirality induced by increasing the polarity of the solvent. [on SciFinder (R)]

M3 - Conference contribution

SP - ORGN-313

BT - Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29

PB - American Chemical Society

CY - Orlando, FL

T2 - 212th ACS National Meeting

Y2 - 25 August 1996 through 29 August 1996

ER -

Chiral synthetic analogs of myosin

Abstract

Conference

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