Abstract
Iterative tandem catalysis is presented as a flexible tool for obtaining chiral macromolecules from racemic or prochiral monomers. Here, we combine lipase-catalyzed ring-opening of -substituted lactones with ruthenium-catalyzed racemization. In a two-pot system, enantioenriched oligomers of 6-methyl--caprolactone were synthesized, which could not have been obtained by enzymatic ring-opening alone. A one-pot experiment proved highly promising in developing a novel route toward enantiopure polyesters.
Original language | English |
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Pages (from-to) | 9964-9965 |
Journal | Journal of the American Chemical Society |
Volume | 127 |
Issue number | 28 |
DOIs | |
Publication status | Published - 2005 |