Chiral oligomers by iterative tandem catalysis

B.A.C. As, van, J. Buijtenen, van, A. Heise, Q.B. Broxterman, G.K.M. Verzijl, A.R.A. Palmans, E.W. Meijer

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)

Abstract

Iterative tandem catalysis is presented as a flexible tool for obtaining chiral macromolecules from racemic or prochiral monomers. Here, we combine lipase-catalyzed ring-opening of -substituted lactones with ruthenium-catalyzed racemization. In a two-pot system, enantioenriched oligomers of 6-methyl--caprolactone were synthesized, which could not have been obtained by enzymatic ring-opening alone. A one-pot experiment proved highly promising in developing a novel route toward enantiopure polyesters.
Original languageEnglish
Pages (from-to)9964-9965
JournalJournal of the American Chemical Society
Volume127
Issue number28
DOIs
Publication statusPublished - 2005

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