Chemoenzymatic synthesis of block copolymers

M. Geus, de, A.R.A. Palmans, C.J. Duxbury, S. Villarroya, S.M. Howdle, A. Heise

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

1 Citation (Scopus)
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Abstract

The chemoenzymatic cascade synthesis of block copolymers combining enzymatic ring opening polymerization (eROP) and atom transfer radical polymerization (ATRP) is reviewed. Factors like reaction condition and initiator structure were investigated and optimized prior to the polymerization. The synthesis of block copolymers was successful in two consecutive steps, i.e. eROP followed by ATRP as evident from SEC and GPEC analysis. While in the one-pot approach, block copolymers could be obtained by sequential addition of the ATRP catalyst, side reactions were observed when all components were present from the start of the reaction. A successful one-pot synthesis was achieved by conducting the reaction in supercritical carbon dioxide
Original languageEnglish
Title of host publicationPolymer biocatalysis and biomaterials II
EditorsH.N. Cheng, R.A. Gross
Place of PublicationWashington
PublisherAmerican Chemical Society
Pages216-229
ISBN (Print)978-0-8412-6970-5
DOIs
Publication statusPublished - 2008

Publication series

NameACS symposium series
Volume999
ISSN (Print)0097-6156

Fingerprint

Atom transfer radical polymerization
Block copolymers
Ring opening polymerization
Carbon Dioxide
Polymerization
Catalysts

Cite this

Geus, de, M., Palmans, A. R. A., Duxbury, C. J., Villarroya, S., Howdle, S. M., & Heise, A. (2008). Chemoenzymatic synthesis of block copolymers. In H. N. Cheng, & R. A. Gross (Eds.), Polymer biocatalysis and biomaterials II (pp. 216-229). (ACS symposium series; Vol. 999). Washington: American Chemical Society. https://doi.org/10.1021/bk-2008-0999.ch014
Geus, de, M. ; Palmans, A.R.A. ; Duxbury, C.J. ; Villarroya, S. ; Howdle, S.M. ; Heise, A. / Chemoenzymatic synthesis of block copolymers. Polymer biocatalysis and biomaterials II. editor / H.N. Cheng ; R.A. Gross. Washington : American Chemical Society, 2008. pp. 216-229 (ACS symposium series).
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Geus, de, M, Palmans, ARA, Duxbury, CJ, Villarroya, S, Howdle, SM & Heise, A 2008, Chemoenzymatic synthesis of block copolymers. in HN Cheng & RA Gross (eds), Polymer biocatalysis and biomaterials II. ACS symposium series, vol. 999, American Chemical Society, Washington, pp. 216-229. https://doi.org/10.1021/bk-2008-0999.ch014

Chemoenzymatic synthesis of block copolymers. / Geus, de, M.; Palmans, A.R.A.; Duxbury, C.J.; Villarroya, S.; Howdle, S.M.; Heise, A.

Polymer biocatalysis and biomaterials II. ed. / H.N. Cheng; R.A. Gross. Washington : American Chemical Society, 2008. p. 216-229 (ACS symposium series; Vol. 999).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

TY - CHAP

T1 - Chemoenzymatic synthesis of block copolymers

AU - Geus, de, M.

AU - Palmans, A.R.A.

AU - Duxbury, C.J.

AU - Villarroya, S.

AU - Howdle, S.M.

AU - Heise, A.

PY - 2008

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AB - The chemoenzymatic cascade synthesis of block copolymers combining enzymatic ring opening polymerization (eROP) and atom transfer radical polymerization (ATRP) is reviewed. Factors like reaction condition and initiator structure were investigated and optimized prior to the polymerization. The synthesis of block copolymers was successful in two consecutive steps, i.e. eROP followed by ATRP as evident from SEC and GPEC analysis. While in the one-pot approach, block copolymers could be obtained by sequential addition of the ATRP catalyst, side reactions were observed when all components were present from the start of the reaction. A successful one-pot synthesis was achieved by conducting the reaction in supercritical carbon dioxide

U2 - 10.1021/bk-2008-0999.ch014

DO - 10.1021/bk-2008-0999.ch014

M3 - Chapter

SN - 978-0-8412-6970-5

T3 - ACS symposium series

SP - 216

EP - 229

BT - Polymer biocatalysis and biomaterials II

A2 - Cheng, H.N.

A2 - Gross, R.A.

PB - American Chemical Society

CY - Washington

ER -

Geus, de M, Palmans ARA, Duxbury CJ, Villarroya S, Howdle SM, Heise A. Chemoenzymatic synthesis of block copolymers. In Cheng HN, Gross RA, editors, Polymer biocatalysis and biomaterials II. Washington: American Chemical Society. 2008. p. 216-229. (ACS symposium series). https://doi.org/10.1021/bk-2008-0999.ch014