Chemical-biological exploration of the limits of the ras de- and repalmitoylating machinery

K. Görmer, M. Bürger, J.A. Kruijtzer, I. Vetter, N. Vartak, L. Brunsveld, P.I.H. Bastiaens, R.M. Liskamp, G. Triola, H. Waldmann

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
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Abstract

A dynamic de-/repalmitoylation cycle determines localization and activity of H- and N-Ras. This combined cellular de- and repalmitoylation machinery has been shown to be substrate tolerant--it accepts variation of amino acid sequence, structure and configuration. Here, semisynthetic Ras-proteins in which the C-terminal amino acids are replaced by peptoid residues are used to reveal the first limitations of substrate recognition by the de- and repalmitoylating machinery.
Original languageEnglish
Pages (from-to)1017-1023
Number of pages7
JournalChemBioChem
Volume13
Issue number7
DOIs
Publication statusPublished - 2012

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