Chelating amphiphilic polymers

Holger Gruell; Anke de Vries; Sander Langereis; Johan Lub; Erica M.G. Aussems-Custers

Chelating amphiphilic polymers

Holger Gruell (Inventor)
, Anke de Vries (Inventor)
, Sander Langereis (Inventor)
, Johan Lub (Inventor)
, Erica M.G. Aussems-Custers (Inventor)

Research output: Patent › Patent publication

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Abstract

Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1/T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

Original language	English
Patent number	US2011165074
IPC	C08F 8/ 32 A I
Priority date	8/09/09
Publication status	Published - 7 Jul 2011

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title = "Chelating amphiphilic polymers",

abstract = "Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1/T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.",

author = "Holger Gruell and \{de Vries\}, Anke and Sander Langereis and Johan Lub and Aussems-Custers, \{Erica M.G.\}",

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language = "English",

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TY - PAT

T1 - Chelating amphiphilic polymers

AU - Gruell, Holger

AU - de Vries, Anke

AU - Langereis, Sander

AU - Lub, Johan

AU - Aussems-Custers, Erica M.G.

PY - 2011/7/7

Y1 - 2011/7/7

N2 - Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1/T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

AB - Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with 5 the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T 1/T 2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

M3 - Patent publication

M1 - US2011165074

ER -

Chelating amphiphilic polymers

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