Challenges and opportunities for enantioselective liquid-liquid extraction

B. Schuur, A.B. Haan, de

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


    The use of liquid-liquid extraction for the separation of enantiomers (ELLE) has been demonstrated as early as 1959. After over a decade without significant improvement (only four articles appeared in the 1960s), Nobel Laureate Donald Cram picked up the concept in the 1970s and published a series of crown-ether based extractants that are very selective towards amino acid esters. After the work of Cram had become famous, more people started working on ELLE, though the field has ever remained small and hardly any work has been reported beyond the exploratory stage. In this paper the most significant improvements of the last 50 years in the field are discussed, including the most remarkable extractants developed for several classes of substrates (amino acid esters, amino alcohols, aromatic acids and amino acids), and process technology to scale up to continuous operation. Future commercialisation seems possible using supported liquid membranes, centrifugal contactor separator technology, or with solvent impregnated resins as hybrid technology.
    Original languageEnglish
    Title of host publicationProceedings of the 19th International Solvent Extraction Conference - ISEC 2011, 3-7 October 2011, Santiago, Chile
    Publication statusPublished - 2011
    Event19th International Solvent Extraction Conference (ISEC 2011), October 3-7, 2011, Santiago, Chile - Santiago, Chile
    Duration: 3 Oct 20117 Oct 2011


    Conference19th International Solvent Extraction Conference (ISEC 2011), October 3-7, 2011, Santiago, Chile
    Abbreviated titleISEC 2011
    Internet address


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