The use of liquid-liquid extraction for the separation of enantiomers (ELLE) has been demonstrated as early as 1959. After over a decade without significant improvement (only four articles appeared in the 1960s), Nobel Laureate Donald Cram picked up the concept in the 1970s and published a series of crown-ether based extractants that are very selective towards amino acid esters. After the work of Cram had become famous, more people started working on ELLE, though the field has ever remained small and hardly any work has been reported beyond the exploratory stage. In this paper the most significant improvements of the last 50 years in the field are discussed, including the most remarkable extractants developed for several classes of substrates (amino acid esters, amino alcohols, aromatic acids and amino acids), and process technology to scale up to continuous operation. Future commercialisation seems possible using supported liquid membranes, centrifugal contactor separator technology, or with solvent impregnated resins as hybrid technology.
|Title of host publication||Proceedings of the 19th International Solvent Extraction Conference - ISEC 2011, 3-7 October 2011, Santiago, Chile|
|Publication status||Published - 2011|
|Event||19th International Solvent Extraction Conference (ISEC 2011), October 3-7, 2011, Santiago, Chile - Santiago, Chile|
Duration: 3 Oct 2011 → 7 Oct 2011
|Conference||19th International Solvent Extraction Conference (ISEC 2011), October 3-7, 2011, Santiago, Chile|
|Abbreviated title||ISEC 2011|
|Period||3/10/11 → 7/10/11|