Cerebral ischemia and white matter edema in experimental hydrocephalus. A combined in vivo MRI and MRS study

K.P.J. Braun; R.M. Dijkhuizen; R.A. Graaf, de; K. Nicolaij; W.P. Vandertop; R.H.J.M. Gooskens; C.A.F. Tulleken

doi:10.1016/S0006-8993(97)00345-4

Cerebral ischemia and white matter edema in experimental hydrocephalus. A combined in vivo MRI and MRS study

K.P.J. Braun, R.M. Dijkhuizen, R.A. Graaf, de, K. Nicolaij, W.P. Vandertop, R.H.J.M. Gooskens, C.A.F. Tulleken

Mechanical Engineering

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Abstract

T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.

Original language	English
Pages (from-to)	295-298
Journal	Brain Research
Volume	757
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(97)00345-4
Publication status	Published - 1997

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title = "Cerebral ischemia and white matter edema in experimental hydrocephalus. A combined in vivo MRI and MRS study",

abstract = "T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.",

author = "K.P.J. Braun and R.M. Dijkhuizen and {Graaf, de}, R.A. and K. Nicolaij and W.P. Vandertop and R.H.J.M. Gooskens and C.A.F. Tulleken",

year = "1997",

doi = "10.1016/S0006-8993(97)00345-4",

language = "English",

volume = "757",

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journal = "Brain Research",

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TY - JOUR

T1 - Cerebral ischemia and white matter edema in experimental hydrocephalus. A combined in vivo MRI and MRS study

AU - Braun, K.P.J.

AU - Dijkhuizen, R.M.

AU - Graaf, de, R.A.

AU - Nicolaij, K.

AU - Vandertop, W.P.

AU - Gooskens, R.H.J.M.

AU - Tulleken, C.A.F.

PY - 1997

Y1 - 1997

N2 - T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.

AB - T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.

U2 - 10.1016/S0006-8993(97)00345-4

DO - 10.1016/S0006-8993(97)00345-4

M3 - Article

SN - 0006-8993

VL - 757

SP - 295

EP - 298

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Cerebral ischemia and white matter edema in experimental hydrocephalus. A combined in vivo MRI and MRS study

Abstract

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