Cerebral ischemia and white matter edema in experimental hydrocephalus. A combined in vivo MRI and MRS study

K.P.J. Braun, R.M. Dijkhuizen, R.A. Graaf, de, K. Nicolaij, W.P. Vandertop, R.H.J.M. Gooskens, C.A.F. Tulleken

Research output: Contribution to journalArticleAcademicpeer-review

52 Citations (Scopus)

Abstract

T2 and diffusion weighted MRI, as well as 31P and 1H MRS were performed in kaolin-induced hydrocephalic rats. Extracellular white matter edema was detected in the early stages of progressive hydrocephalus. Phosphocreatine (PCr)/inorganic phosphate (Pi) ratios in hydrocephalic animals were decreased compared to controls, and lactate was detected during the acute and chronic stages of hydrocephalus. These MR spectroscopic results are indicative of a compromised energy metabolism and suggest the occurrence of cerebral ischemia in experimental hydrocephalus.
Original languageEnglish
Pages (from-to)295-298
JournalBrain Research
Volume757
Issue number2
DOIs
Publication statusPublished - 1997

Fingerprint Dive into the research topics of 'Cerebral ischemia and white matter edema in experimental hydrocephalus. A combined in vivo MRI and MRS study'. Together they form a unique fingerprint.

Cite this