The mechanism by which cells receive and respond to molecules is known as cell signaling. By understanding the fundamentals of cell signaling, tissue engineers can better direct cell behavior. This chapter primarily focuses on how the soluble and insoluble components of the extracellular matrix interact with cell receptors to induce specific intracellular signaling cascades that result in changed behavior or protein expression. The major pathways involved in skin, vascular, and bone regeneration, and in muscle force transduction are outlined, along with examples of how tissue engineers can exploit cell signaling.
|Title of host publication||Tissue Engineering|
|Number of pages||38|
|Publication status||Published - 10 Dec 2014|
- Cell surface receptors
- Extracellular matrix
- Growth factors
- Signal transduction