Cellular Signaling

Vanessa L.S. LaPointe, Jan De Boer, Adam J. Engler

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

The mechanism by which cells receive and respond to molecules is known as cell signaling. By understanding the fundamentals of cell signaling, tissue engineers can better direct cell behavior. This chapter primarily focuses on how the soluble and insoluble components of the extracellular matrix interact with cell receptors to induce specific intracellular signaling cascades that result in changed behavior or protein expression. The major pathways involved in skin, vascular, and bone regeneration, and in muscle force transduction are outlined, along with examples of how tissue engineers can exploit cell signaling.

Original languageEnglish
Title of host publicationTissue Engineering
PublisherElsevier
Pages111-148
Number of pages38
Edition2nd
ISBN (Print)9780124201453
DOIs
Publication statusPublished - 10 Dec 2014
Externally publishedYes

Keywords

  • Cell surface receptors
  • Extracellular matrix
  • Growth factors
  • Signal transduction
  • Transcription

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