Cellular Signaling

Vanessa L.S. LaPointe, Jan de Boer, Adam J. Engler

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

1 Citation (Scopus)


The mechanism by which cells receive and respond to molecules is known as cell signaling. By understanding the fundamentals of cell signaling, tissue engineers can better direct cell behavior. This chapter primarily focuses on how the soluble and insoluble components of the extracellular matrix interact with cell receptors to induce specific intracellular signaling cascades that result in changed behavior or protein expression. The major pathways involved in skin, vascular, and bone regeneration, and in muscle force transduction are outlined, along with examples of how tissue engineers can exploit cell signaling.

Original languageEnglish
Title of host publicationTissue Engineering
Number of pages38
ISBN (Print)9780124201453
Publication statusPublished - 10 Dec 2014
Externally publishedYes


  • Cell surface receptors
  • Extracellular matrix
  • Growth factors
  • Signal transduction
  • Transcription


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