Cellular integration of an enzyme-loaded polymersome nanoreactor

S.F.M. van Dongen, W.P.R. Verdurmen, R.J.R.W. Peters, R.J.M. Nolte, R. Brock, J.C.M. van Hest

    Research output: Contribution to journalArticleAcademicpeer-review

    108 Citations (Scopus)

    Abstract

    Cells with implants: Porous enzyme-loaded polymersomes were constructed that display the cell-penetrating peptide tat on their surfaces. These nanoreactors are taken up by mammalian cells through macropinocytosis. Inside the cells, the polymersomes are only partially routed to acidic compartments. Polymersomes with horseradish peroxidase as a model cargo enzyme displayed sustained intracellular activity.

    Original languageEnglish
    Pages (from-to)7213-7216
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume49
    Issue number40
    DOIs
    Publication statusPublished - 24 Sep 2010

    Keywords

    • Bioorganic chemistry
    • Cell-penetrating peptides
    • Nanotechnology
    • Polymersomes

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