Cellular integration of an enzyme-loaded polymersome nanoreactor

S.F.M. van Dongen, W.P.R. Verdurmen, R.J.R.W. Peters, R.J.M. Nolte, R. Brock, J.C.M. van Hest

Research output: Contribution to journalArticleAcademicpeer-review

114 Citations (Scopus)

Abstract

Cells with implants: Porous enzyme-loaded polymersomes were constructed that display the cell-penetrating peptide tat on their surfaces. These nanoreactors are taken up by mammalian cells through macropinocytosis. Inside the cells, the polymersomes are only partially routed to acidic compartments. Polymersomes with horseradish peroxidase as a model cargo enzyme displayed sustained intracellular activity.

Original languageEnglish
Pages (from-to)7213-7216
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number40
DOIs
Publication statusPublished - 24 Sep 2010

Keywords

  • Bioorganic chemistry
  • Cell-penetrating peptides
  • Nanotechnology
  • Polymersomes

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