Cell deformation in response to long-term hyperosmotic loading

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Abstract

Hypertrophic and elongated cells are found in differentiation zones of load-bearing tissues, where tissue is hyperosmotic. In this paper we study if, in response to long-term hyperosmotic loading, cells are affected with hypertophy or elongation, and whether these response are cell-specific. Surface adhesion and elongation of CHO-K1 and C2C12 cells were determinde with CLSM, after 2 and 5 days of culture in 380 mOsmol medium. Results show that both cell types increase an adhesion area (p0.1). Conclusively all cells hypertrophy, but do not elongate under hyperosmotic loading. Quantitatively, CHO-K1 cells respond more than C2C12 cells.
Original languageEnglish
Pages (from-to)3-11
JournalActa of Bioengineering and Biomechanics
Volume5
Issue number1
Publication statusPublished - 2003

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