cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells

A.C. Vertegaal, H.B. Kuiperij, T. Laar, van, V. Scharnhorst, A.J. Eb, van der, A. Zantema

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Proteins encoded by non-oncogenic adenovirus type 5 and oncogenic adenovirus type 12 differentially affect expression of a number of cellular genes. We have used cDNA micro array analysis to identify a cellular gene that is expressed in Ad12- but not in Ad5-transformed cells. This cellular gene was found to be the gene encoding follistatin-related protein, a TGF-ß inducible gene. Consistently, a constitutive factor binding to Smad binding elements was found in adenovirus type 12-transformed cells.
Original languageEnglish
Pages (from-to)151-155
JournalFEBS Letters
Volume487
Issue number2
DOIs
Publication statusPublished - 2000

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