Catalyst recycling via hydrogen-bonding-based affinity tags

B.W.T. Gruijters, M.A.C. Broeren, F.L. Delft, van, R.P. Sijbesma, P.H.H. Hermkens, F.P.J.T. Rutjes

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)
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A novel procedure for catalyst recycling is described. Copper(I)-based catalysts, equipped with an affinity tag, are isolated from crude reaction mixtures on the basis of quadruple hydrogen-bonding interactions using a resin functionalized with complementary affinity tags. Recycled catalysts were successfully used to catalyze a tandem Sonogashira coupling/5-endo-dig cyclization and a Cu-catalyzed [3+2] Huisgen cycloaddition reaction in high yields.
Original languageEnglish
Pages (from-to)3163-3166
Number of pages4
JournalOrganic Letters
Issue number15
Publication statusPublished - 2006


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