Carotid plaque assessment using non-invasive shear strain elastography

M.H.G. Heusinkveld, M.H. Roy Cardinal, Yang Ju, Zhao Qin, R.G.P. Lopata, G. Soulez, G. Cloutier

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


Stroke is a leading cause of death and morbidity worldwide, and a significant proportion of strokes are caused by carotid atherosclerotic plaque rupture. Non-invasive vascular elastography (NIVE) provides maps of carotid plaque strain computed from radiofrequency ultrasound (US) data sequences. The goal of this project was to evaluate the ability of NIVE shear strain analysis to characterize carotid plaque vulnerability in vivo in patients referred for carotid evaluation. A total of 31 patients with a severe stenosis of the internal carotid artery (> 50%) were enrolled in this study. Twodimensional radiofrequency data were obtained to perform NIVE and to calculate the axial, lateral and shear strains. High-resolution magnetic resonance (MR) images were acquired to segment and quantify the plaques and their internal components. The analysis of plaque regions experiencing large shear strains showed a statistically significant difference (p = 0.046) between symptomatic and asymptomatic patient groups. Statistically significant differences were also found between the time average shear elastogram (Mean |SSE|) of vulnerable versus non-vulnerable plaques without inflammation (p = 0.036). The Mean |SSE| of non-vulnerable plaques with and without inflammation were also significantly different (p = 0.008). The proposed shear measures have the potential to help identifying vulnerable plaques and vulnerable patients.

Original languageEnglish
Title of host publicationIEEE International Ultrasonics Symposium, IUS
PublisherIEEE Computer Society
Number of pages4
ISBN (Electronic)9781479970490
Publication statusPublished - 20 Oct 2014
Event2014 IEEE International Ultrasonics Symposium (IUS 2014) - Hilton Hotel, Chicago, United States
Duration: 3 Sept 20146 Sept 2014


Conference2014 IEEE International Ultrasonics Symposium (IUS 2014)
Abbreviated titleIUS 2014
Country/TerritoryUnited States
Internet address


  • carotid artery atherosclerosis
  • Shear strain elastography
  • stroke
  • symptomatic patients
  • vulnerable plaques


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