Cardiac progenitor cells and the interplay with their microenvironment

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells. In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche. We focus on the interaction between CPCs and supporting cells,
extracellular matrix, mechanical stimuli, and soluble factors. Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity.
LanguageEnglish
Article number7471582
Number of pages20
JournalStem Cells International
Volume2017
DOIs
StatePublished - 2017

Cite this

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title = "Cardiac progenitor cells and the interplay with their microenvironment",
abstract = "The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells. In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche. We focus on the interaction between CPCs and supporting cells,extracellular matrix, mechanical stimuli, and soluble factors. Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity.",
author = "A. Mauretti and S. Spaans and N.A.M. Bax and C. Sahlgren and C.V.C. Bouten",
year = "2017",
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journal = "Stem Cells International",
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Cardiac progenitor cells and the interplay with their microenvironment. / Mauretti, A.; Spaans, S.; Bax, N.A.M.; Sahlgren, C.; Bouten, C.V.C.

In: Stem Cells International, Vol. 2017, 7471582, 2017.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

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AU - Mauretti,A.

AU - Spaans,S.

AU - Bax,N.A.M.

AU - Sahlgren,C.

AU - Bouten,C.V.C.

PY - 2017

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AB - The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells. In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche. We focus on the interaction between CPCs and supporting cells,extracellular matrix, mechanical stimuli, and soluble factors. Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity.

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DO - 10.1155/2017/7471582

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JO - Stem Cells International

T2 - Stem Cells International

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