Abstract
Nanocomposite hydrogels based on carbon nanotubes (CNTs) are known to possess remarkable stiffness, electrical, and thermal conductivity. However, they often make use of CNTs as fillers in covalently cross-linked hydrogel networks or involve direct cross-linking between CNTs and polymer chains, limiting processability properties. Herein, nanocomposite hydrogels are developed, in which CNTs are fillers in a physically cross-linked hydrogel. Supramolecular nanocomposites are prepared at various CNT concentrations, ranging from 0.5 to 6 wt%. Incorporation of 3 wt% of CNTs leads to an increase of the material’s toughness by over 80%, and it enhances electrical conductivity by 358%, compared to CNT-free hydrogel. Meanwhile, the nanocomposite hydrogels maintain thixotropy and processability, typical of the parent hydrogel. The study also demonstrates that these materials display remarkable cytocompatibility and support cell growth and proliferation, while preserving their functional activities. These supramolecular nanocomposite hydrogels are therefore promising candidates for biomedical applications, in which both toughness and electrical conductivity are important parameters.
| Original language | English |
|---|---|
| Article number | 1800173 |
| Number of pages | 12 |
| Journal | Macromolecular Bioscience |
| Volume | 19 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
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Keywords
- biocompatibility
- electrical conductivity
- multi-walled carbon nanotubes
- nanocomposite supramolecular hydrogel
- tensile toughness
- Cell Line
- Humans
- Hydrogels/chemistry
- Nanotubes, Carbon/chemistry
- Electric Conductivity
- Nanocomposites/chemistry
Cite this
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Carbon nanotube reinforced supramolecular hydrogels for bioapplications. / Mihajlovic, Marko; Mihajlovic, Milos; Dankers, Patricia Y.W.; Masereeuw, Rosalinde; Sijbesma, Rint P. (Corresponding author).
In: Macromolecular Bioscience, Vol. 19, 1800173, 01.01.2019.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Carbon nanotube reinforced supramolecular hydrogels for bioapplications
AU - Mihajlovic, Marko
AU - Mihajlovic, Milos
AU - Dankers, Patricia Y.W.
AU - Masereeuw, Rosalinde
AU - Sijbesma, Rint P.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Nanocomposite hydrogels based on carbon nanotubes (CNTs) are known to possess remarkable stiffness, electrical, and thermal conductivity. However, they often make use of CNTs as fillers in covalently cross-linked hydrogel networks or involve direct cross-linking between CNTs and polymer chains, limiting processability properties. Herein, nanocomposite hydrogels are developed, in which CNTs are fillers in a physically cross-linked hydrogel. Supramolecular nanocomposites are prepared at various CNT concentrations, ranging from 0.5 to 6 wt%. Incorporation of 3 wt% of CNTs leads to an increase of the material’s toughness by over 80%, and it enhances electrical conductivity by 358%, compared to CNT-free hydrogel. Meanwhile, the nanocomposite hydrogels maintain thixotropy and processability, typical of the parent hydrogel. The study also demonstrates that these materials display remarkable cytocompatibility and support cell growth and proliferation, while preserving their functional activities. These supramolecular nanocomposite hydrogels are therefore promising candidates for biomedical applications, in which both toughness and electrical conductivity are important parameters.
AB - Nanocomposite hydrogels based on carbon nanotubes (CNTs) are known to possess remarkable stiffness, electrical, and thermal conductivity. However, they often make use of CNTs as fillers in covalently cross-linked hydrogel networks or involve direct cross-linking between CNTs and polymer chains, limiting processability properties. Herein, nanocomposite hydrogels are developed, in which CNTs are fillers in a physically cross-linked hydrogel. Supramolecular nanocomposites are prepared at various CNT concentrations, ranging from 0.5 to 6 wt%. Incorporation of 3 wt% of CNTs leads to an increase of the material’s toughness by over 80%, and it enhances electrical conductivity by 358%, compared to CNT-free hydrogel. Meanwhile, the nanocomposite hydrogels maintain thixotropy and processability, typical of the parent hydrogel. The study also demonstrates that these materials display remarkable cytocompatibility and support cell growth and proliferation, while preserving their functional activities. These supramolecular nanocomposite hydrogels are therefore promising candidates for biomedical applications, in which both toughness and electrical conductivity are important parameters.
KW - biocompatibility
KW - electrical conductivity
KW - multi-walled carbon nanotubes
KW - nanocomposite supramolecular hydrogel
KW - tensile toughness
KW - Cell Line
KW - Humans
KW - Hydrogels/chemistry
KW - Nanotubes, Carbon/chemistry
KW - Electric Conductivity
KW - Nanocomposites/chemistry
UR - http://www.scopus.com/inward/record.url?scp=85052483392&partnerID=8YFLogxK
U2 - 10.1002/mabi.201800173
DO - 10.1002/mabi.201800173
M3 - Article
C2 - 30085403
AN - SCOPUS:85052483392
VL - 19
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
SN - 1616-5187
M1 - 1800173
ER -