Cancer-on-chip models for metastasis: importance of the tumor microenvironment

Mohammad Jouy Bar; Charlotte M. de Winde; Katarina Wolf; Peter Friedl; Reina Mebius; Jaap M.J. den Toonder

doi:10.1016/j.tibtech.2023.10.001

Cancer-on-chip models for metastasis: importance of the tumor microenvironment

Mohammad Jouy Bar, Charlotte M. de Winde, Katarina Wolf, Peter Friedl, Reina Mebius, Jaap M.J. den Toonder (Corresponding author)

Research output: Contribution to journal › Review article › peer-review

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Abstract

Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for 3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC models are therefore increasingly used to systematically study effects of the TME on the various steps in cancer metastasis. Moreover, CoC models have great potential for developing novel cancer therapies and for predicting patient-specific response to cancer treatments. We review recent developments in CoC models, focusing on three main TME components: (i) the anisotropic extracellular matrix (ECM) architectures, (ii) the vasculature, and (iii) the immune system. We aim to provide guidance to biologists to choose the best CoC approach for addressing questions about the role of the TME in metastasis, and to inspire engineers to develop novel CoC technologies.

Original language	English
Pages (from-to)	431-448
Number of pages	18
Journal	Trends in Biotechnology
Volume	42
Issue number	4
Early online date	31 Oct 2023
DOIs	https://doi.org/10.1016/j.tibtech.2023.10.001
Publication status	Published - Apr 2024

Funding

We thank the Animation Study of TU Eindhoven for the graphic design of the figures. The work of M.J. is part of the Moore4Medical project funded by the ECSEL Joint Undertaking under grant number H2020-ECSEL-2019-IA-876190 . C.M.dW. is supported by the Cancer Center Amsterdam (grant no. CCA2019-9-57 and CCA2020-9-73 ) and the Dutch Cancer Foundation (KWF; Young Investigator Grant no. 2022-4 EXPL/14641 ). K.W. is supported by a grant from the Dutch Cancer Foundation KWF (grant number 11199 ). J.M.J.dT. and P.F. are supported by a grant from the Dutch Research Council NWO (grant number Science-XL 2019.022 , \u2018The Active Matter Physics of Collective Metastasis\u2019).

Funders	Funder number
KWF Dutch Cancer Society	11199
KWF Kankerbestrijding	2022-4 EXPL/14641
Netherlands Cancer Institute	CCA2019-9-57, CCA2020-9-73

Keywords

Cancer-on-chip
tumor microenvironment
extracellular matrix
vasculature
immune system

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tibtech.2023.10.001

pdfFinal published version, 5.03 MBLicence: CC BY
Cancer-on-chip models for metastasis_ importance of the tumor microenvironment

Cite this

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title = "Cancer-on-chip models for metastasis: importance of the tumor microenvironment",

abstract = "Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for 3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC models are therefore increasingly used to systematically study effects of the TME on the various steps in cancer metastasis. Moreover, CoC models have great potential for developing novel cancer therapies and for predicting patient-specific response to cancer treatments. We review recent developments in CoC models, focusing on three main TME components: (i) the anisotropic extracellular matrix (ECM) architectures, (ii) the vasculature, and (iii) the immune system. We aim to provide guidance to biologists to choose the best CoC approach for addressing questions about the role of the TME in metastasis, and to inspire engineers to develop novel CoC technologies.",

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AU - Jouy Bar, Mohammad

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AU - Mebius, Reina

AU - den Toonder, Jaap M.J.

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AB - Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for 3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC models are therefore increasingly used to systematically study effects of the TME on the various steps in cancer metastasis. Moreover, CoC models have great potential for developing novel cancer therapies and for predicting patient-specific response to cancer treatments. We review recent developments in CoC models, focusing on three main TME components: (i) the anisotropic extracellular matrix (ECM) architectures, (ii) the vasculature, and (iii) the immune system. We aim to provide guidance to biologists to choose the best CoC approach for addressing questions about the role of the TME in metastasis, and to inspire engineers to develop novel CoC technologies.

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Cancer-on-chip models for metastasis: importance of the tumor microenvironment

Abstract

Funding

Keywords

UN SDGs

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