Cancer intravasation-on-a-chip : a LEGO house for tumors!

H. Eslami Amirabadi; Sh. Sahebali; A.L.W. Miggiels; J.Ph. Frimat; R. Luttge; J. den Toonder

Cancer intravasation-on-a-chip : a LEGO house for tumors!

H. Eslami Amirabadi
, Sh. Sahebali
, A.L.W. Miggiels
, J.Ph. Frimat
, R. Luttge
, J. den Toonder

Research output: Contribution to conference › Poster

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Abstract

The process where cancer cells leave the primary tumor and invade to the blood vessel. As shown in figure 1, intravasation is highly regulated by the micro-environment of the tumor. An important component of the micro-environment is the extracellular matrix (ECM) which can be seen as the building structure of a LEGO house. A proper model for cancer intravasation requires a proper model for the micro-environment, or in other words, a right LEGO house for cancer cells to live in! To model the process, microfluidics is used because there is:
•more control on the biochemical content,
•less human error by automating the experiments,
•more complex designs,
•and less ethical issues, it is a LEGO house!
The GOAL is to study how the mechanical properties of the extracellular matrix regulate the tumor intravasation by using a microfluidic chip.

Original language	English
Publication status	Published - Nov 2015

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SDG 3 Good Health and Well-being

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title = "Cancer intravasation-on-a-chip : a LEGO house for tumors!",

abstract = "The process where cancer cells leave the primary tumor and invade to the blood vessel. As shown in figure 1, intravasation is highly regulated by the micro-environment of the tumor. An important component of the micro-environment is the extracellular matrix (ECM) which can be seen as the building structure of a LEGO house. A proper model for cancer intravasation requires a proper model for the micro-environment, or in other words, a right LEGO house for cancer cells to live in! To model the process, microfluidics is used because there is: •more control on the biochemical content, •less human error by automating the experiments, •more complex designs, •and less ethical issues, it is a LEGO house! The GOAL is to study how the mechanical properties of the extracellular matrix regulate the tumor intravasation by using a microfluidic chip.",

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TY - CONF

T1 - Cancer intravasation-on-a-chip : a LEGO house for tumors!

AU - Eslami Amirabadi, H.

AU - Sahebali, Sh.

AU - Miggiels, A.L.W.

AU - Frimat, J.Ph.

AU - Luttge, R.

AU - den Toonder, J.

PY - 2015/11

Y1 - 2015/11

N2 - The process where cancer cells leave the primary tumor and invade to the blood vessel. As shown in figure 1, intravasation is highly regulated by the micro-environment of the tumor. An important component of the micro-environment is the extracellular matrix (ECM) which can be seen as the building structure of a LEGO house. A proper model for cancer intravasation requires a proper model for the micro-environment, or in other words, a right LEGO house for cancer cells to live in! To model the process, microfluidics is used because there is: •more control on the biochemical content, •less human error by automating the experiments, •more complex designs, •and less ethical issues, it is a LEGO house! The GOAL is to study how the mechanical properties of the extracellular matrix regulate the tumor intravasation by using a microfluidic chip.

AB - The process where cancer cells leave the primary tumor and invade to the blood vessel. As shown in figure 1, intravasation is highly regulated by the micro-environment of the tumor. An important component of the micro-environment is the extracellular matrix (ECM) which can be seen as the building structure of a LEGO house. A proper model for cancer intravasation requires a proper model for the micro-environment, or in other words, a right LEGO house for cancer cells to live in! To model the process, microfluidics is used because there is: •more control on the biochemical content, •less human error by automating the experiments, •more complex designs, •and less ethical issues, it is a LEGO house! The GOAL is to study how the mechanical properties of the extracellular matrix regulate the tumor intravasation by using a microfluidic chip.

M3 - Poster

ER -

Cancer intravasation-on-a-chip : a LEGO house for tumors!

Abstract

UN SDGs

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