Cancer intravasation-on-a-chip : a LEGO house for tumors!

H. Eslami Amirabadi, Sh. Sahebali, A.L.W. Miggiels, J.Ph. Frimat, R. Luttge, J. den Toonder

Research output: Contribution to conferencePosterAcademic

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Abstract

The process where cancer cells leave the primary tumor and invade to the blood vessel. As shown in figure 1, intravasation is highly regulated by the micro-environment of the tumor. An important component of the micro-environment is the extracellular matrix (ECM) which can be seen as the building structure of a LEGO house. A proper model for cancer intravasation requires a proper model for the micro-environment, or in other words, a right LEGO house for cancer cells to live in! To model the process, microfluidics is used because there is:
•more control on the biochemical content,
•less human error by automating the experiments,
•more complex designs,
•and less ethical issues, it is a LEGO house!
The GOAL is to study how the mechanical properties of the extracellular matrix regulate the tumor intravasation by using a microfluidic chip.
Original languageEnglish
Publication statusPublished - Nov 2015

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