Can we use in vivo MRI and FEA to determine peak cap stress in carotid plaques? MRI simulations provide answers

H.A. Nieuwstadt; J.W. Wentzel; A. van der Lugt; A.F.W. van der Steen; M. Breeuwer; F.J.H. Gijsen

doi:10.1115/SBC2013-14114

Can we use in vivo MRI and FEA to determine peak cap stress in carotid plaques? MRI simulations provide answers

H.A. Nieuwstadt, J.W. Wentzel, A. van der Lugt, A.F.W. van der Steen, M. Breeuwer, F.J.H. Gijsen

Medical Image Analysis

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

Vulnerable plaques are characterized by a large lipid-rich necrotic core (LRNC) separated by a thin fibrous cap (FC) from the lumen. Plaque rupture occurs when the peak stress in the FC exceeds its strength. Carotid in vivo magnetic resonance imaging (MRI) data can be segmented to obtain the plaque geometry noninvasively. An increasing number of studies use MR imaging for biomechanical finite element analysis (FEA) to compute peak cap stresses [1, 2]. Previous studies have shown that the thickness of the FC is an important determinant of peak cap stress: the thinner the FC, the higher the stress, the higher the plaque rupture risk [3].

Original language	English
Title of host publication	ASME 2013 Summer Bioengineering Conference, SBC 2013
Publisher	American Society of Mechanical Engineers
Number of pages	2
Volume	1 B
ISBN (Print)	9780791855614
DOIs	https://doi.org/10.1115/SBC2013-14114
Publication status	Published - 2013
Event	ASME 2013 Summer Bioengineering Conference SBC 2013 - Sunriver, United States Duration: 26 Jun 2013 → 29 Jun 2013 http://www.asmeconferences.org/SBC2013/

Conference

Conference	ASME 2013 Summer Bioengineering Conference SBC 2013
Abbreviated title	SBC 2013
Country/Territory	United States
City	Sunriver
Period	26/06/13 → 29/06/13
Internet address	http://www.asmeconferences.org/SBC2013/

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Nieuwstadt, H. A., Wentzel, J. W., van der Lugt, A., van der Steen, A. F. W., Breeuwer, M., & Gijsen, F. J. H. (2013). Can we use in vivo MRI and FEA to determine peak cap stress in carotid plaques? MRI simulations provide answers. In ASME 2013 Summer Bioengineering Conference, SBC 2013 (Vol. 1 B). American Society of Mechanical Engineers. https://doi.org/10.1115/SBC2013-14114

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title = "Can we use in vivo MRI and FEA to determine peak cap stress in carotid plaques? MRI simulations provide answers",

abstract = "Vulnerable plaques are characterized by a large lipid-rich necrotic core (LRNC) separated by a thin fibrous cap (FC) from the lumen. Plaque rupture occurs when the peak stress in the FC exceeds its strength. Carotid in vivo magnetic resonance imaging (MRI) data can be segmented to obtain the plaque geometry noninvasively. An increasing number of studies use MR imaging for biomechanical finite element analysis (FEA) to compute peak cap stresses [1, 2]. Previous studies have shown that the thickness of the FC is an important determinant of peak cap stress: the thinner the FC, the higher the stress, the higher the plaque rupture risk [3].",

author = "H.A. Nieuwstadt and J.W. Wentzel and {van der Lugt}, A. and {van der Steen}, A.F.W. and M. Breeuwer and F.J.H. Gijsen",

year = "2013",

doi = "10.1115/SBC2013-14114",

language = "English",

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volume = "1 B",

booktitle = "ASME 2013 Summer Bioengineering Conference, SBC 2013",

publisher = "American Society of Mechanical Engineers",

address = "United States",

note = "ASME 2013 Summer Bioengineering Conference SBC 2013, SBC 2013 ; Conference date: 26-06-2013 Through 29-06-2013",

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Nieuwstadt, HA, Wentzel, JW, van der Lugt, A, van der Steen, AFW, Breeuwer, M & Gijsen, FJH 2013, Can we use in vivo MRI and FEA to determine peak cap stress in carotid plaques? MRI simulations provide answers. in ASME 2013 Summer Bioengineering Conference, SBC 2013. vol. 1 B, American Society of Mechanical Engineers, ASME 2013 Summer Bioengineering Conference SBC 2013, Sunriver, Oregon, United States, 26/06/13. https://doi.org/10.1115/SBC2013-14114

Can we use in vivo MRI and FEA to determine peak cap stress in carotid plaques? MRI simulations provide answers. / Nieuwstadt, H.A.; Wentzel, J.W.; van der Lugt, A.; van der Steen, A.F.W.; Breeuwer, M.; Gijsen, F.J.H.

ASME 2013 Summer Bioengineering Conference, SBC 2013. Vol. 1 B American Society of Mechanical Engineers, 2013.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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T1 - Can we use in vivo MRI and FEA to determine peak cap stress in carotid plaques? MRI simulations provide answers

AU - Nieuwstadt, H.A.

AU - Wentzel, J.W.

AU - van der Lugt, A.

AU - van der Steen, A.F.W.

AU - Breeuwer, M.

AU - Gijsen, F.J.H.

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N2 - Vulnerable plaques are characterized by a large lipid-rich necrotic core (LRNC) separated by a thin fibrous cap (FC) from the lumen. Plaque rupture occurs when the peak stress in the FC exceeds its strength. Carotid in vivo magnetic resonance imaging (MRI) data can be segmented to obtain the plaque geometry noninvasively. An increasing number of studies use MR imaging for biomechanical finite element analysis (FEA) to compute peak cap stresses [1, 2]. Previous studies have shown that the thickness of the FC is an important determinant of peak cap stress: the thinner the FC, the higher the stress, the higher the plaque rupture risk [3].

AB - Vulnerable plaques are characterized by a large lipid-rich necrotic core (LRNC) separated by a thin fibrous cap (FC) from the lumen. Plaque rupture occurs when the peak stress in the FC exceeds its strength. Carotid in vivo magnetic resonance imaging (MRI) data can be segmented to obtain the plaque geometry noninvasively. An increasing number of studies use MR imaging for biomechanical finite element analysis (FEA) to compute peak cap stresses [1, 2]. Previous studies have shown that the thickness of the FC is an important determinant of peak cap stress: the thinner the FC, the higher the stress, the higher the plaque rupture risk [3].

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AN - SCOPUS:84894658915

SN - 9780791855614

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BT - ASME 2013 Summer Bioengineering Conference, SBC 2013

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T2 - ASME 2013 Summer Bioengineering Conference SBC 2013

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ER -

Can we use in vivo MRI and FEA to determine peak cap stress in carotid plaques? MRI simulations provide answers

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