Can we use in vivo MRI and FEA to determine peak cap stress in carotid plaques? MRI simulations provide answers

H.A. Nieuwstadt, J.W. Wentzel, A. van der Lugt, A.F.W. van der Steen, M. Breeuwer, F.J.H. Gijsen

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Vulnerable plaques are characterized by a large lipid-rich necrotic core (LRNC) separated by a thin fibrous cap (FC) from the lumen. Plaque rupture occurs when the peak stress in the FC exceeds its strength. Carotid in vivo magnetic resonance imaging (MRI) data can be segmented to obtain the plaque geometry noninvasively. An increasing number of studies use MR imaging for biomechanical finite element analysis (FEA) to compute peak cap stresses [1, 2]. Previous studies have shown that the thickness of the FC is an important determinant of peak cap stress: the thinner the FC, the higher the stress, the higher the plaque rupture risk [3].
Original languageEnglish
Title of host publicationASME 2013 Summer Bioengineering Conference, SBC 2013
PublisherAmerican Society of Mechanical Engineers
Number of pages2
Volume1 B
ISBN (Print)9780791855614
DOIs
Publication statusPublished - 2013
EventASME 2013 Summer Bioengineering Conference (SBC 2013) - Sunriver, United States
Duration: 26 Jun 201329 Jun 2013
http://www.asmeconferences.org/SBC2013/

Conference

ConferenceASME 2013 Summer Bioengineering Conference (SBC 2013)
Abbreviated titleSBC 2013
CountryUnited States
CitySunriver
Period26/06/1329/06/13
Internet address

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