Breast cancer cells with distinct E-cadherin status exhibit different 3-D invasion behavior in a novel microfluidic system

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Abstract

Different E-cadherin status in breast cancer is associated with different invasion abilities. However, a relevant in vitro study to study this is still missing from the literature. We developed a microfluidic system to characterize the invasion of three breast cancer cell lines with distinct E-cadherin status in 3D under the influence of a chemotactic gradient. We showed that this system can be used to capture the cells’ migration ability and invasion pattern. Using a perfusion system to control chemotactic gradients and integration of a 3D extracellular matrix, we could mimic two essential components of the tumor microenvironment during cancer invasion.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1658-1660
Number of pages3
Volume3
ISBN (Electronic)9781510897571
Publication statusPublished - 1 Jan 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung Exhibition Center, Kaohsiung, Taiwan
Duration: 11 Nov 201815 Nov 2018
https://cbmsociety.org/conferences/microtas2018/

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Country/TerritoryTaiwan
CityKaohsiung
Period11/11/1815/11/18
Internet address

Keywords

  • Breast cancer cell invasion
  • Chemotactic gradient
  • E-cadherin
  • Invasion mode
  • Microfluidics

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