Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease

Dario Arnaldi (Corresponding author), Sanne K. Meles, Alessandro Giuliani, Silvia Morbelli, Remco J. Renken, Annette Janzen, Elisabeth Sittig-Wiegand, Candan Depboylu, Kathrin Reetz, Sebastiaan Overeem, Angelique Pijpers, Fransje E. Reesink, Teus Van Laar, Laura K. Teune, Helmut Höffken, Marcus Luster, Lars Timmermann, Karl Kesper, Sofie M. Adriaanse, Jan Booij & 2 others Gianmario Sambuceti, Nicola Girtler

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function. Methods: Thirty-six iRBD patients (64.1±6.5 y, 32 M), 72 PD patients, and 79 controls (65.6±9.4 y, 53 M) underwent brain 18 F-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4±8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8±6.6 y, 29 M) of RBD. 18F-FDG-PET scans were used to independently discriminate subjects belonging to four categories: Controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes). Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions. Conclusion: Data-driven approach to brain 18 F-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.

LanguageEnglish
Pages229-239
Number of pages11
JournalJournal of Parkinson's Disease
Volume9
Issue number1
DOIs
StatePublished - 1 Jan 2019

Keywords

  • F-FDG-PET
  • Parkinson's disease
  • REM sleep behavior disorder
  • synucleinopathy

Cite this

Arnaldi, D., Meles, S. K., Giuliani, A., Morbelli, S., Renken, R. J., Janzen, A., ... Girtler, N. (2019). Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease. Journal of Parkinson's Disease, 9(1), 229-239. DOI: 10.3233/JPD-181468
Arnaldi, Dario ; Meles, Sanne K. ; Giuliani, Alessandro ; Morbelli, Silvia ; Renken, Remco J. ; Janzen, Annette ; Sittig-Wiegand, Elisabeth ; Depboylu, Candan ; Reetz, Kathrin ; Overeem, Sebastiaan ; Pijpers, Angelique ; Reesink, Fransje E. ; Van Laar, Teus ; Teune, Laura K. ; Höffken, Helmut ; Luster, Marcus ; Timmermann, Lars ; Kesper, Karl ; Adriaanse, Sofie M. ; Booij, Jan ; Sambuceti, Gianmario ; Girtler, Nicola. / Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease. In: Journal of Parkinson's Disease. 2019 ; Vol. 9, No. 1. pp. 229-239
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title = "Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease",
abstract = "Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function. Methods: Thirty-six iRBD patients (64.1±6.5 y, 32 M), 72 PD patients, and 79 controls (65.6±9.4 y, 53 M) underwent brain 18 F-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4±8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8±6.6 y, 29 M) of RBD. 18F-FDG-PET scans were used to independently discriminate subjects belonging to four categories: Controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes). Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions. Conclusion: Data-driven approach to brain 18 F-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.",
keywords = "F-FDG-PET, Parkinson's disease, REM sleep behavior disorder, synucleinopathy",
author = "Dario Arnaldi and Meles, {Sanne K.} and Alessandro Giuliani and Silvia Morbelli and Renken, {Remco J.} and Annette Janzen and Elisabeth Sittig-Wiegand and Candan Depboylu and Kathrin Reetz and Sebastiaan Overeem and Angelique Pijpers and Reesink, {Fransje E.} and {Van Laar}, Teus and Teune, {Laura K.} and Helmut H{\"o}ffken and Marcus Luster and Lars Timmermann and Karl Kesper and Adriaanse, {Sofie M.} and Jan Booij and Gianmario Sambuceti and Nicola Girtler",
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Arnaldi, D, Meles, SK, Giuliani, A, Morbelli, S, Renken, RJ, Janzen, A, Sittig-Wiegand, E, Depboylu, C, Reetz, K, Overeem, S, Pijpers, A, Reesink, FE, Van Laar, T, Teune, LK, Höffken, H, Luster, M, Timmermann, L, Kesper, K, Adriaanse, SM, Booij, J, Sambuceti, G & Girtler, N 2019, 'Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease' Journal of Parkinson's Disease, vol. 9, no. 1, pp. 229-239. DOI: 10.3233/JPD-181468

Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease. / Arnaldi, Dario (Corresponding author); Meles, Sanne K.; Giuliani, Alessandro; Morbelli, Silvia; Renken, Remco J.; Janzen, Annette; Sittig-Wiegand, Elisabeth; Depboylu, Candan; Reetz, Kathrin; Overeem, Sebastiaan; Pijpers, Angelique; Reesink, Fransje E.; Van Laar, Teus; Teune, Laura K.; Höffken, Helmut; Luster, Marcus; Timmermann, Lars; Kesper, Karl; Adriaanse, Sofie M.; Booij, Jan; Sambuceti, Gianmario; Girtler, Nicola.

In: Journal of Parkinson's Disease, Vol. 9, No. 1, 01.01.2019, p. 229-239.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease

AU - Arnaldi,Dario

AU - Meles,Sanne K.

AU - Giuliani,Alessandro

AU - Morbelli,Silvia

AU - Renken,Remco J.

AU - Janzen,Annette

AU - Sittig-Wiegand,Elisabeth

AU - Depboylu,Candan

AU - Reetz,Kathrin

AU - Overeem,Sebastiaan

AU - Pijpers,Angelique

AU - Reesink,Fransje E.

AU - Van Laar,Teus

AU - Teune,Laura K.

AU - Höffken,Helmut

AU - Luster,Marcus

AU - Timmermann,Lars

AU - Kesper,Karl

AU - Adriaanse,Sofie M.

AU - Booij,Jan

AU - Sambuceti,Gianmario

AU - Girtler,Nicola

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function. Methods: Thirty-six iRBD patients (64.1±6.5 y, 32 M), 72 PD patients, and 79 controls (65.6±9.4 y, 53 M) underwent brain 18 F-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4±8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8±6.6 y, 29 M) of RBD. 18F-FDG-PET scans were used to independently discriminate subjects belonging to four categories: Controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes). Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions. Conclusion: Data-driven approach to brain 18 F-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.

AB - Background/Objective: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function. Methods: Thirty-six iRBD patients (64.1±6.5 y, 32 M), 72 PD patients, and 79 controls (65.6±9.4 y, 53 M) underwent brain 18 F-FDG-PET. PD patients were divided according to the absence (PD, 32 subjects; 68.4±8.5 y, 15 M) or presence (PDRBD, 40 subjects; 71.8±6.6 y, 29 M) of RBD. 18F-FDG-PET scans were used to independently discriminate subjects belonging to four categories: Controls (RBD no, PD no), iRBD (RBD yes, PD no), PD (RBD no, PD yes) and PDRBD (RBD yes, PD yes). Results: The discriminant analysis was moderately accurate in identifying the correct category. This is because the model mostly confounds iRBD and PD, thus the intermediate classes. Indeed, iRBD, PD and PDRBD were progressively located at increasing distance from controls and are ordered along a single dimension (principal coordinate analysis) indicating the presence of a single flux of variation encompassing both RBD and PD conditions. Conclusion: Data-driven approach to brain 18 F-FDG-PET showed only moderate discrimination between iRBD and PD patients, highlighting brain glucose metabolism heterogeneity among such patients. iRBD should be considered as a marker of an ongoing condition that may be picked-up in different stages across patients and thus express different brain imaging features and likely different clinical trajectories.

KW - F-FDG-PET

KW - Parkinson's disease

KW - REM sleep behavior disorder

KW - synucleinopathy

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U2 - 10.3233/JPD-181468

DO - 10.3233/JPD-181468

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Arnaldi D, Meles SK, Giuliani A, Morbelli S, Renken RJ, Janzen A et al. Brain glucose metabolism heterogeneity in idiopathic REM sleep behavior disorder and in Parkinson's disease. Journal of Parkinson's Disease. 2019 Jan 1;9(1):229-239. Available from, DOI: 10.3233/JPD-181468