TY - JOUR
T1 - Bone structural changes in osteoarthritis as a result of mechanoregulated bone adaptation: a modeling approach
AU - Cox, L.G.E.
AU - Rietbergen, van, B.
AU - Donkelaar, van, C.C.
AU - Ito, K.
PY - 2011
Y1 - 2011
N2 - Objective
There are strong indications that subchondral bone may play an important role in osteoarthritis (OA), making it an interesting target for medical therapies. The subchondral bone structure changes markedly during OA, and it has long been assumed that this occurs secondary to cartilage degeneration. However, for various conditions that are associated with OA, it is known that they may also induce bone structural changes in the absence of cartilage degeneration. We therefore aimed to investigate if OA bone structural changes can result from mechanoregulated bone adaptation, independent of cartilage degeneration.
Method
With a bone adaptation model, we simulated various conditions associated with OA –without altering the articular cartilage– and we evaluated if mechanoregulated bone remodeling by itself could lead to OA-like bone structural changes.
Results
For each of the conditions, the predicted changes in bone structural parameters (bone fraction, trabecular thickness, trabecular number, and trabecular separation) were similar to those observed in OA.
Conclusion
This indicates that bone adaptation in OA can be mechanoregulated with structural changes occurring independent of cartilage degeneration.
Keywords: Osteoarthritis; Bone architecture; Computer Simulation; Remodeling; Mechanoregulation
AB - Objective
There are strong indications that subchondral bone may play an important role in osteoarthritis (OA), making it an interesting target for medical therapies. The subchondral bone structure changes markedly during OA, and it has long been assumed that this occurs secondary to cartilage degeneration. However, for various conditions that are associated with OA, it is known that they may also induce bone structural changes in the absence of cartilage degeneration. We therefore aimed to investigate if OA bone structural changes can result from mechanoregulated bone adaptation, independent of cartilage degeneration.
Method
With a bone adaptation model, we simulated various conditions associated with OA –without altering the articular cartilage– and we evaluated if mechanoregulated bone remodeling by itself could lead to OA-like bone structural changes.
Results
For each of the conditions, the predicted changes in bone structural parameters (bone fraction, trabecular thickness, trabecular number, and trabecular separation) were similar to those observed in OA.
Conclusion
This indicates that bone adaptation in OA can be mechanoregulated with structural changes occurring independent of cartilage degeneration.
Keywords: Osteoarthritis; Bone architecture; Computer Simulation; Remodeling; Mechanoregulation
U2 - 10.1016/j.joca.2011.02.007
DO - 10.1016/j.joca.2011.02.007
M3 - Article
C2 - 21324371
SN - 1063-4584
VL - 19
SP - 676
EP - 682
JO - Osteoarthritis and Cartilage
JF - Osteoarthritis and Cartilage
IS - 6
ER -