Bone mineralization after strontium and fluoride treatment in osteoporosis

E. Rokita; P.H.A. Mutsaers; J.A. Quaedackers; G. Tato; M.J.A. Voigt, de

doi:10.1016/S0168-583X(99)00361-4

Bone mineralization after strontium and fluoride treatment in osteoporosis

E. Rokita, P.H.A. Mutsaers, J.A. Quaedackers, G. Tato, M.J.A. Voigt, de

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and with proton induced gamma-ray emission (micro-PIGE) are used to determine quantitatively the modulation of inorganic deposits formation by Sr and F ions in a cell culture model. The results indicate that the process may be investigated by the micro-PIXE determination of the amount of calcium deposited. It was found that F-treatment stimulate bone formation at doses much lower than Sr. At high doses an impaired mineralization is found for both elements. It was found that the mechanisms responsible for of F and Sr incorporations are different. The minimal F and Sr concentrations in the medium at which the incorporation may be investigated by micro-PIGE and micro-PIXE amount to 0.02 mg/l and

Original language	English
Pages (from-to)	412-417
Number of pages	5
Journal	Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volume	158
Issue number	1-4
DOIs	https://doi.org/10.1016/S0168-583X(99)00361-4
Publication status	Published - 1999

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title = "Bone mineralization after strontium and fluoride treatment in osteoporosis",

abstract = "The proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and with proton induced gamma-ray emission (micro-PIGE) are used to determine quantitatively the modulation of inorganic deposits formation by Sr and F ions in a cell culture model. The results indicate that the process may be investigated by the micro-PIXE determination of the amount of calcium deposited. It was found that F-treatment stimulate bone formation at doses much lower than Sr. At high doses an impaired mineralization is found for both elements. It was found that the mechanisms responsible for of F and Sr incorporations are different. The minimal F and Sr concentrations in the medium at which the incorporation may be investigated by micro-PIGE and micro-PIXE amount to 0.02 mg/l and",

author = "E. Rokita and P.H.A. Mutsaers and J.A. Quaedackers and G. Tato and {Voigt, de}, M.J.A.",

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doi = "10.1016/S0168-583X(99)00361-4",

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TY - JOUR

T1 - Bone mineralization after strontium and fluoride treatment in osteoporosis

AU - Rokita, E.

AU - Mutsaers, P.H.A.

AU - Quaedackers, J.A.

AU - Tato, G.

AU - Voigt, de, M.J.A.

PY - 1999

Y1 - 1999

N2 - The proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and with proton induced gamma-ray emission (micro-PIGE) are used to determine quantitatively the modulation of inorganic deposits formation by Sr and F ions in a cell culture model. The results indicate that the process may be investigated by the micro-PIXE determination of the amount of calcium deposited. It was found that F-treatment stimulate bone formation at doses much lower than Sr. At high doses an impaired mineralization is found for both elements. It was found that the mechanisms responsible for of F and Sr incorporations are different. The minimal F and Sr concentrations in the medium at which the incorporation may be investigated by micro-PIGE and micro-PIXE amount to 0.02 mg/l and

AB - The proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and with proton induced gamma-ray emission (micro-PIGE) are used to determine quantitatively the modulation of inorganic deposits formation by Sr and F ions in a cell culture model. The results indicate that the process may be investigated by the micro-PIXE determination of the amount of calcium deposited. It was found that F-treatment stimulate bone formation at doses much lower than Sr. At high doses an impaired mineralization is found for both elements. It was found that the mechanisms responsible for of F and Sr incorporations are different. The minimal F and Sr concentrations in the medium at which the incorporation may be investigated by micro-PIGE and micro-PIXE amount to 0.02 mg/l and

U2 - 10.1016/S0168-583X(99)00361-4

DO - 10.1016/S0168-583X(99)00361-4

M3 - Article

SN - 0168-583X

VL - 158

SP - 412

EP - 417

JO - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

IS - 1-4

ER -

Bone mineralization after strontium and fluoride treatment in osteoporosis

Abstract

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