Bone mineralization after strontium and fluoride treatment in osteoporosis

E. Rokita, P.H.A. Mutsaers, J.A. Quaedackers, G. Tato, M.J.A. Voigt, de

    Research output: Contribution to journalArticleAcademicpeer-review

    8 Citations (Scopus)

    Abstract

    The proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and with proton induced gamma-ray emission (micro-PIGE) are used to determine quantitatively the modulation of inorganic deposits formation by Sr and F ions in a cell culture model. The results indicate that the process may be investigated by the micro-PIXE determination of the amount of calcium deposited. It was found that F-treatment stimulate bone formation at doses much lower than Sr. At high doses an impaired mineralization is found for both elements. It was found that the mechanisms responsible for of F and Sr incorporations are different. The minimal F and Sr concentrations in the medium at which the incorporation may be investigated by micro-PIGE and micro-PIXE amount to 0.02 mg/l and
    LanguageEnglish
    Pages412-417
    Number of pages5
    JournalNuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
    Volume158
    Issue number1-4
    DOIs
    StatePublished - 1999

    Fingerprint

    osteoporosis
    Strontium
    strontium
    bones
    fluorides
    Bone
    Protons
    protons
    X rays
    Gamma rays
    gamma rays
    osteogenesis
    dosage
    x rays
    Cell culture
    calcium
    Calcium
    Deposits
    deposits
    Modulation

    Cite this

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    title = "Bone mineralization after strontium and fluoride treatment in osteoporosis",
    abstract = "The proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and with proton induced gamma-ray emission (micro-PIGE) are used to determine quantitatively the modulation of inorganic deposits formation by Sr and F ions in a cell culture model. The results indicate that the process may be investigated by the micro-PIXE determination of the amount of calcium deposited. It was found that F-treatment stimulate bone formation at doses much lower than Sr. At high doses an impaired mineralization is found for both elements. It was found that the mechanisms responsible for of F and Sr incorporations are different. The minimal F and Sr concentrations in the medium at which the incorporation may be investigated by micro-PIGE and micro-PIXE amount to 0.02 mg/l and",
    author = "E. Rokita and P.H.A. Mutsaers and J.A. Quaedackers and G. Tato and {Voigt, de}, M.J.A.",
    year = "1999",
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    language = "English",
    volume = "158",
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    Bone mineralization after strontium and fluoride treatment in osteoporosis. / Rokita, E.; Mutsaers, P.H.A.; Quaedackers, J.A.; Tato, G.; Voigt, de, M.J.A.

    In: Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, Vol. 158, No. 1-4, 1999, p. 412-417.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Bone mineralization after strontium and fluoride treatment in osteoporosis

    AU - Rokita,E.

    AU - Mutsaers,P.H.A.

    AU - Quaedackers,J.A.

    AU - Tato,G.

    AU - Voigt, de,M.J.A.

    PY - 1999

    Y1 - 1999

    N2 - The proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and with proton induced gamma-ray emission (micro-PIGE) are used to determine quantitatively the modulation of inorganic deposits formation by Sr and F ions in a cell culture model. The results indicate that the process may be investigated by the micro-PIXE determination of the amount of calcium deposited. It was found that F-treatment stimulate bone formation at doses much lower than Sr. At high doses an impaired mineralization is found for both elements. It was found that the mechanisms responsible for of F and Sr incorporations are different. The minimal F and Sr concentrations in the medium at which the incorporation may be investigated by micro-PIGE and micro-PIXE amount to 0.02 mg/l and

    AB - The proton microprobe in combination with proton induced X-ray emission (micro-PIXE) and with proton induced gamma-ray emission (micro-PIGE) are used to determine quantitatively the modulation of inorganic deposits formation by Sr and F ions in a cell culture model. The results indicate that the process may be investigated by the micro-PIXE determination of the amount of calcium deposited. It was found that F-treatment stimulate bone formation at doses much lower than Sr. At high doses an impaired mineralization is found for both elements. It was found that the mechanisms responsible for of F and Sr incorporations are different. The minimal F and Sr concentrations in the medium at which the incorporation may be investigated by micro-PIGE and micro-PIXE amount to 0.02 mg/l and

    U2 - 10.1016/S0168-583X(99)00361-4

    DO - 10.1016/S0168-583X(99)00361-4

    M3 - Article

    VL - 158

    SP - 412

    EP - 417

    JO - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

    T2 - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

    JF - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

    SN - 0168-583X

    IS - 1-4

    ER -