Bone microarchitecture and distal radius fracture pattern complexity

Anne M. Daniels (Corresponding author), Luuk M.A. Theelen, Caroline E. Wyers, Heinrich M.J. Janzing, Bert van Rietbergen, Lisanne Vranken, Robert Y. van der Velde, Piet P.M.M. Geusens, Sjoerd Kaarsemaker, Martijn Poeze, Joop P. van den Bergh

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Distal radius fractures (DRFs) occur in various complexity patterns among patients differing in age, gender, and bone mineral density (BMD). Our aim was to investigate the association of patient characteristics, BMD, bone microarchitecture, and bone strength with the pattern complexity of DRFs. In this study, 251 patients aged 50-90 years with a radiologically confirmed DRF who attended the Fracture Liaison Service of VieCuri Medical Centre, the Netherlands, between November 2013 and June 2016 were included. In all patients fracture risk factors and underling metabolic disorders were evaluated and BMD measurement with vertebral fractures assessment by dual-energy X-ray absorptiometry was performed. Radiographs of all DRFs were reviewed by two independent investigators to assess fracture pattern complexity according to the AO/OTA classification in extra-articular (A), partially articular (B), and complete articular (C) fractures. For this study, patients with A and C fractures were compared. Seventy-one patients were additionally assessed by high-resolution peripheral quantitative computed tomography. Compared to group A, mean age, the proportion of males, and current smokers were higher in group C, but BMD and prevalent vertebral fractures were not different. In univariate analyses, age, male gender, trabecular area, volumetric BMD (vBMD), and stiffness were associated with type C fractures. In multivariate analyses, only male gender (odds ratio (OR) 8.48 95% confidence interval (CI) 1.75-41.18, p = 0.008]) and age (OR 1.11 [95% CI 1.03-1.19, p = 0.007]) were significantly associated with DRF pattern complexity. In conclusion, our data demonstrate that age and gender, but not body mass index, BMD, bone microarchitecture, or strength were associated with pattern complexity of DRFs.

LanguageEnglish
Pages1690-1697
JournalJournal of Orthopaedic Research
Volume37
Issue number8
Early online date12 Apr 2019
DOIs
StatePublished - 10 Jul 2019

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Radius Fractures
Bone Density
Bone and Bones
Joints
Odds Ratio
Confidence Intervals
Photon Absorptiometry
Netherlands
Body Mass Index
Multivariate Analysis
Tomography
Research Personnel

Cite this

Daniels, A. M., Theelen, L. M. A., Wyers, C. E., Janzing, H. M. J., van Rietbergen, B., Vranken, L., ... van den Bergh, J. P. (2019). Bone microarchitecture and distal radius fracture pattern complexity. Journal of Orthopaedic Research, 37(8), 1690-1697. DOI: 10.1002/jor.24306
Daniels, Anne M. ; Theelen, Luuk M.A. ; Wyers, Caroline E. ; Janzing, Heinrich M.J. ; van Rietbergen, Bert ; Vranken, Lisanne ; van der Velde, Robert Y. ; Geusens, Piet P.M.M. ; Kaarsemaker, Sjoerd ; Poeze, Martijn ; van den Bergh, Joop P./ Bone microarchitecture and distal radius fracture pattern complexity. In: Journal of Orthopaedic Research. 2019 ; Vol. 37, No. 8. pp. 1690-1697
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title = "Bone microarchitecture and distal radius fracture pattern complexity",
abstract = "Distal radius fractures (DRFs) occur in various complexity patterns among patients differing in age, gender, and bone mineral density (BMD). Our aim was to investigate the association of patient characteristics, BMD, bone microarchitecture, and bone strength with the pattern complexity of DRFs. In this study, 251 patients aged 50-90 years with a radiologically confirmed DRF who attended the Fracture Liaison Service of VieCuri Medical Centre, the Netherlands, between November 2013 and June 2016 were included. In all patients fracture risk factors and underling metabolic disorders were evaluated and BMD measurement with vertebral fractures assessment by dual-energy X-ray absorptiometry was performed. Radiographs of all DRFs were reviewed by two independent investigators to assess fracture pattern complexity according to the AO/OTA classification in extra-articular (A), partially articular (B), and complete articular (C) fractures. For this study, patients with A and C fractures were compared. Seventy-one patients were additionally assessed by high-resolution peripheral quantitative computed tomography. Compared to group A, mean age, the proportion of males, and current smokers were higher in group C, but BMD and prevalent vertebral fractures were not different. In univariate analyses, age, male gender, trabecular area, volumetric BMD (vBMD), and stiffness were associated with type C fractures. In multivariate analyses, only male gender (odds ratio (OR) 8.48 95{\%} confidence interval (CI) 1.75-41.18, p = 0.008]) and age (OR 1.11 [95{\%} CI 1.03-1.19, p = 0.007]) were significantly associated with DRF pattern complexity. In conclusion, our data demonstrate that age and gender, but not body mass index, BMD, bone microarchitecture, or strength were associated with pattern complexity of DRFs.",
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Daniels, AM, Theelen, LMA, Wyers, CE, Janzing, HMJ, van Rietbergen, B, Vranken, L, van der Velde, RY, Geusens, PPMM, Kaarsemaker, S, Poeze, M & van den Bergh, JP 2019, 'Bone microarchitecture and distal radius fracture pattern complexity' Journal of Orthopaedic Research, vol. 37, no. 8, pp. 1690-1697. DOI: 10.1002/jor.24306

Bone microarchitecture and distal radius fracture pattern complexity. / Daniels, Anne M. (Corresponding author); Theelen, Luuk M.A.; Wyers, Caroline E.; Janzing, Heinrich M.J.; van Rietbergen, Bert; Vranken, Lisanne; van der Velde, Robert Y.; Geusens, Piet P.M.M.; Kaarsemaker, Sjoerd; Poeze, Martijn; van den Bergh, Joop P.

In: Journal of Orthopaedic Research, Vol. 37, No. 8, 10.07.2019, p. 1690-1697.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Daniels,Anne M.

AU - Theelen,Luuk M.A.

AU - Wyers,Caroline E.

AU - Janzing,Heinrich M.J.

AU - van Rietbergen,Bert

AU - Vranken,Lisanne

AU - van der Velde,Robert Y.

AU - Geusens,Piet P.M.M.

AU - Kaarsemaker,Sjoerd

AU - Poeze,Martijn

AU - van den Bergh,Joop P.

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Y1 - 2019/7/10

N2 - Distal radius fractures (DRFs) occur in various complexity patterns among patients differing in age, gender, and bone mineral density (BMD). Our aim was to investigate the association of patient characteristics, BMD, bone microarchitecture, and bone strength with the pattern complexity of DRFs. In this study, 251 patients aged 50-90 years with a radiologically confirmed DRF who attended the Fracture Liaison Service of VieCuri Medical Centre, the Netherlands, between November 2013 and June 2016 were included. In all patients fracture risk factors and underling metabolic disorders were evaluated and BMD measurement with vertebral fractures assessment by dual-energy X-ray absorptiometry was performed. Radiographs of all DRFs were reviewed by two independent investigators to assess fracture pattern complexity according to the AO/OTA classification in extra-articular (A), partially articular (B), and complete articular (C) fractures. For this study, patients with A and C fractures were compared. Seventy-one patients were additionally assessed by high-resolution peripheral quantitative computed tomography. Compared to group A, mean age, the proportion of males, and current smokers were higher in group C, but BMD and prevalent vertebral fractures were not different. In univariate analyses, age, male gender, trabecular area, volumetric BMD (vBMD), and stiffness were associated with type C fractures. In multivariate analyses, only male gender (odds ratio (OR) 8.48 95% confidence interval (CI) 1.75-41.18, p = 0.008]) and age (OR 1.11 [95% CI 1.03-1.19, p = 0.007]) were significantly associated with DRF pattern complexity. In conclusion, our data demonstrate that age and gender, but not body mass index, BMD, bone microarchitecture, or strength were associated with pattern complexity of DRFs.

AB - Distal radius fractures (DRFs) occur in various complexity patterns among patients differing in age, gender, and bone mineral density (BMD). Our aim was to investigate the association of patient characteristics, BMD, bone microarchitecture, and bone strength with the pattern complexity of DRFs. In this study, 251 patients aged 50-90 years with a radiologically confirmed DRF who attended the Fracture Liaison Service of VieCuri Medical Centre, the Netherlands, between November 2013 and June 2016 were included. In all patients fracture risk factors and underling metabolic disorders were evaluated and BMD measurement with vertebral fractures assessment by dual-energy X-ray absorptiometry was performed. Radiographs of all DRFs were reviewed by two independent investigators to assess fracture pattern complexity according to the AO/OTA classification in extra-articular (A), partially articular (B), and complete articular (C) fractures. For this study, patients with A and C fractures were compared. Seventy-one patients were additionally assessed by high-resolution peripheral quantitative computed tomography. Compared to group A, mean age, the proportion of males, and current smokers were higher in group C, but BMD and prevalent vertebral fractures were not different. In univariate analyses, age, male gender, trabecular area, volumetric BMD (vBMD), and stiffness were associated with type C fractures. In multivariate analyses, only male gender (odds ratio (OR) 8.48 95% confidence interval (CI) 1.75-41.18, p = 0.008]) and age (OR 1.11 [95% CI 1.03-1.19, p = 0.007]) were significantly associated with DRF pattern complexity. In conclusion, our data demonstrate that age and gender, but not body mass index, BMD, bone microarchitecture, or strength were associated with pattern complexity of DRFs.

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SN - 0736-0266

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Daniels AM, Theelen LMA, Wyers CE, Janzing HMJ, van Rietbergen B, Vranken L et al. Bone microarchitecture and distal radius fracture pattern complexity. Journal of Orthopaedic Research. 2019 Jul 10;37(8):1690-1697. Available from, DOI: 10.1002/jor.24306