Bone disease during chronic antiepileptic drug therapy: general versus specific risk factors

K. Beerhorst; S.J.M. Kruijs, van der; P. Verschuure; IY Tan; A.P. Aldenkamp

doi:10.1016/j.jns.2013.05.005

Bone disease during chronic antiepileptic drug therapy: general versus specific risk factors

K. Beerhorst
, S.J.M. Kruijs, van der
, P. Verschuure
, IY Tan
, A.P. Aldenkamp

Research output: Contribution to journal › Article › Academic › peer-review

39 Citations (Scopus)

Abstract

An increasing number of studies suggest a direct effect of antiepileptic drug (AED) therapy on bone health: Patients on chronic AED therapy may have an increased risk of fractures, reduced bone mineral density, osteopenia, and osteoporosis. In an attempt to distinguish general and specific risk factors, this review examines the available empirical research. The pathophysiology is discussed and guidelines for early detection and treatment options are proposed.

Original language	English
Pages (from-to)	19-25
Journal	Journal of the Neurological Sciences
Volume	331
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2013.05.005
Publication status	Published - 2013

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10.1016/j.jns.2013.05.005

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title = "Bone disease during chronic antiepileptic drug therapy: general versus specific risk factors",

abstract = "An increasing number of studies suggest a direct effect of antiepileptic drug (AED) therapy on bone health: Patients on chronic AED therapy may have an increased risk of fractures, reduced bone mineral density, osteopenia, and osteoporosis. In an attempt to distinguish general and specific risk factors, this review examines the available empirical research. The pathophysiology is discussed and guidelines for early detection and treatment options are proposed.",

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AU - Tan, IY

AU - Aldenkamp, A.P.

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AB - An increasing number of studies suggest a direct effect of antiepileptic drug (AED) therapy on bone health: Patients on chronic AED therapy may have an increased risk of fractures, reduced bone mineral density, osteopenia, and osteoporosis. In an attempt to distinguish general and specific risk factors, this review examines the available empirical research. The pathophysiology is discussed and guidelines for early detection and treatment options are proposed.

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Bone disease during chronic antiepileptic drug therapy: general versus specific risk factors

Abstract

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