TY - JOUR
T1 - Bone disease during chronic antiepileptic drug therapy: general versus specific risk factors
AU - Beerhorst, K.
AU - Kruijs, van der, S.J.M.
AU - Verschuure, P.
AU - Tan, IY
AU - Aldenkamp, A.P.
PY - 2013
Y1 - 2013
N2 - An increasing number of studies suggest a direct effect of antiepileptic drug (AED) therapy on bone health: Patients on chronic AED therapy may have an increased risk of fractures, reduced bone mineral density, osteopenia, and osteoporosis. In an attempt to distinguish general and specific risk factors, this review examines the available empirical research. The pathophysiology is discussed and guidelines for early detection and treatment options are proposed.
AB - An increasing number of studies suggest a direct effect of antiepileptic drug (AED) therapy on bone health: Patients on chronic AED therapy may have an increased risk of fractures, reduced bone mineral density, osteopenia, and osteoporosis. In an attempt to distinguish general and specific risk factors, this review examines the available empirical research. The pathophysiology is discussed and guidelines for early detection and treatment options are proposed.
U2 - 10.1016/j.jns.2013.05.005
DO - 10.1016/j.jns.2013.05.005
M3 - Article
C2 - 23706474
SN - 0022-510X
VL - 331
SP - 19
EP - 25
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -