Bone-adhesive materials: clinical requirements, mechanisms of action, and future perspective

María J. Sánchez-Fernández, Hussein Hammoudeh, Rosa P. Félix Lanao, Machteld van Erk, Jan C.M. van Hest, Sander C.G. Leeuwenburgh (Corresponding author)

Research output: Contribution to journalReview articleAcademicpeer-review

7 Citations (Scopus)
89 Downloads (Pure)

Abstract

Each year, millions of people suffer from complex bone fractures which require proper external or internal fixation. This fixation is usually achieved by means of devices such as plates, pins, and screws. These traditional fixation strategies are associated with severe drawbacks, which have prompted research and development of a variety of bone-adhesive biomaterials as alternative. However, a clinically applicable bone-adhesive biomaterial—in the form of a bone-glue or bone-adhesive membrane—that meets all requirements has not yet been identified. This perspective article discusses the current state of the art of bone-adhesive materials with a particular focus on their clinical requirements, mechanisms of action, and future perspective. To develop adhesive biomaterials with specific affinity to bone tissue, a more rational design should be implemented. This perspective article is intended as a starting point and inspiration for future research and development of suitable bone-adhesive materials.

Original languageEnglish
Article number1802021
Number of pages11
JournalAdvanced Materials Interfaces
Volume6
Issue number4
DOIs
Publication statusPublished - 22 Feb 2019

Keywords

  • adhesive biomaterials
  • bone adhesive
  • bone repair
  • glue
  • tissue adhesive

Fingerprint Dive into the research topics of 'Bone-adhesive materials: clinical requirements, mechanisms of action, and future perspective'. Together they form a unique fingerprint.

Cite this