Biomimetic radical polymerization via cooperative assembly of segregating templates

R. McHale, J.P. Patterson, P.B. Zetterlund, R.K. O'Reilly

Research output: Contribution to journalArticleAcademicpeer-review

96 Citations (Scopus)

Abstract

Segregation and templating approaches have been honed by billions of years of evolution to direct many complex biological processes. Nature uses segregation to improve biochemical control by organizing reactants into defined, well-regulated environments, and the transfer of genetic information is a primary function of templating. The ribosome, wherein messenger RNA is translated into polypeptides, combines both techniques to allow for ideal biopolymer syntheses. Herein is presented a biomimetic segregation/templating approach to synthetic radical polymerization. Polymerization of a nucleobase-containing vinyl monomer in the presence of a complementary block copolymer template of low molecular weight yields high molecular weight (M w up to ∼400,000 g mol -1), extremely low polydispersity (≤1.08) daughter polymers. Control is attained by segregation of propagating radicals in discrete micelle cores (via cooperative assembly of dynamic template polymers). Significantly reduced bimolecular termination, combined with controlled propagation along a defined number of templates, ensures unprecedented control to afford well-defined high molecular weight polymers.

Original languageEnglish
Pages (from-to)491-497
Number of pages7
JournalNature Chemistry
Volume4
Issue number6
DOIs
Publication statusPublished - Jun 2012
Externally publishedYes

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Biomimetics
Free radical polymerization
Polymers
Molecular weight
Biopolymers
Polypeptides
Polydispersity
Micelles
Block copolymers
Monomers
Polymerization
Messenger RNA
Peptides

Cite this

McHale, R., Patterson, J. P., Zetterlund, P. B., & O'Reilly, R. K. (2012). Biomimetic radical polymerization via cooperative assembly of segregating templates. Nature Chemistry, 4(6), 491-497. https://doi.org/10.1038/nchem.1331
McHale, R. ; Patterson, J.P. ; Zetterlund, P.B. ; O'Reilly, R.K. / Biomimetic radical polymerization via cooperative assembly of segregating templates. In: Nature Chemistry. 2012 ; Vol. 4, No. 6. pp. 491-497.
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McHale, R, Patterson, JP, Zetterlund, PB & O'Reilly, RK 2012, 'Biomimetic radical polymerization via cooperative assembly of segregating templates', Nature Chemistry, vol. 4, no. 6, pp. 491-497. https://doi.org/10.1038/nchem.1331

Biomimetic radical polymerization via cooperative assembly of segregating templates. / McHale, R.; Patterson, J.P.; Zetterlund, P.B.; O'Reilly, R.K.

In: Nature Chemistry, Vol. 4, No. 6, 06.2012, p. 491-497.

Research output: Contribution to journalArticleAcademicpeer-review

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