Biomedical applications of photo- and sono-activated Rose Bengal: a review

Noemi Vanerio, Marco Stijnen, Bas A.J.M. de Mol, Linda M. Kock (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). Background data: RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. Methods: This study is a literature review using the database PubMed. Results: As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. Conclusions: This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.

LanguageEnglish
Pages383-394
Number of pages12
JournalPhotobiomodulation, Photomedicine, and Laser Surgery
Volume37
Issue number7
DOIs
StatePublished - 1 Jul 2019

Fingerprint

Rose Bengal
Oncology
Xanthenes
Photodynamic therapy
Oxygen
Photosensitizers
Tissue engineering
Animals
Therapeutics
Dyes
Irradiation
Tauopathies
Tissue
Methyl Green
Molecules
Photosensitizing Agents
Photochemotherapy
Tissue Engineering
PubMed
Reactive Oxygen Species

Keywords

  • photochemical tissue bonding
  • photodynamic therapy
  • photothrombosis
  • Rose Bengal
  • sonodynamic therapy

Cite this

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title = "Biomedical applications of photo- and sono-activated Rose Bengal: a review",
abstract = "Objective: The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). Background data: RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. Methods: This study is a literature review using the database PubMed. Results: As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. Conclusions: This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.",
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Biomedical applications of photo- and sono-activated Rose Bengal : a review. / Vanerio, Noemi; Stijnen, Marco; de Mol, Bas A.J.M.; Kock, Linda M. (Corresponding author).

In: Photobiomodulation, Photomedicine, and Laser Surgery, Vol. 37, No. 7, 01.07.2019, p. 383-394.

Research output: Contribution to journalArticleAcademicpeer-review

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