Biomedical applications of photo- and sono-activated Rose Bengal: a review

Noemi Vanerio, Marco Stijnen, Bas A.J.M. de Mol, Linda M. Kock (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)
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Objective: The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). Background data: RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. Methods: This study is a literature review using the database PubMed. Results: As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. Conclusions: This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.

Original languageEnglish
Pages (from-to)383-394
Number of pages12
JournalPhotobiomodulation, Photomedicine, and Laser Surgery
Issue number7
Publication statusPublished - 1 Jul 2019


  • photochemical tissue bonding
  • photodynamic therapy
  • photothrombosis
  • Rose Bengal
  • sonodynamic therapy
  • Photosensitizing Agents
  • Humans
  • Photochemotherapy/methods

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