Biomaterial-driven kidney organoid maturation

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Abstract

Differentiation of human-induced pluripotent stem cells (hiPSCs) toward kidney organoids is known to suffer from batch-to-batch differences, off-target populations, and skewered cellular compositions. Application of synthetic hydrogels as a tool for hiPSC-differentiation may provide additional control over this variable process. This review discusses important material properties that affect kidney organoid generation. We summarize cellular adhesive cues for synthetic materials, that allow transduction of the mechanical forces to the cell, and how these signals directly affect Hippo-Canonical Wnt signaling and morphogenic events. In addition, chemical strategies are discussed that allow spatiotemporal presentation of biochemical agents to the cell in a material-dependent approach.

Original languageEnglish
Article number100355
Number of pages10
JournalCurrent Opinion in Biomedical Engineering
Volume21
DOIs
Publication statusPublished - Mar 2022

Bibliographical note

Funding Information:
This work was funded by the Ministry of Education, Culture and Science (Gravity Programs 024.001.035 and 024.003.013), by the partners of Regenerative Medicine Crossing Borders (RegMed XB) powered by Health∼Holland , Top Sector Life Sciences & Health , and a NWO VIDI grant from the Netherlands Organization for Scientific Research (NWO, 723.016.008). The figures were made with BioRender software.

Keywords

  • Biomaterials
  • hiPSC
  • Kidney organoids

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