Biologically active polymersomes from amphiphilic glycopeptides

J. Huang, C. Bonduelle, J. Thevenot, S. Lecommandoux, A. Heise

Research output: Contribution to journalArticleAcademicpeer-review

207 Citations (Scopus)
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Abstract

Polypeptide block copolymers with different block length ratios were obtained by sequential ring-opening polymerization of benzyl-L-glutamate and propargylglycine (PG) N-carboxyanhydrides. Glycosylation of the poly(PG) block was obtained by Huisgens cycloaddition "click" reaction using azide-functionalized galactose. All copolymers were self-assembled using the nanoprecipitation method to obtain spherical and wormlike micelles as well as polymersomes depending on the block length ratio and the nanoprecipitation conditions. These structures display bioactive galactose units in the polymersome shell, as proven by selective lectin binding experiments
Original languageEnglish
Pages (from-to)119-122
JournalJournal of the American Chemical Society
Volume134
Issue number1
DOIs
Publication statusPublished - 2012

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