TY - JOUR
T1 - Biological responses to multilayered DNA-coatings
AU - Beucken, van den, J.J.J.P.
AU - Walboomers, X.F.
AU - Vos, M.R.J.
AU - Sommerdijk, N.A.J.M.
AU - Nolte, R.J.M.
AU - Jansen, J.A.
PY - 2007
Y1 - 2007
N2 - This paper discusses our work on the reduction of nitric oxide (NO) by heme groups immobilized on electrode surfaces, which has been conducted in search for selective NO reduction catalysts. Results show two reduction pathways, one leading to the formation of N2O and another leading to the formation of NH2OH. By changing the conditions (pH, potential, NO concentration and immobilization method), 100% selectivity toward either N2O or NH2OH can be obtained. A difference compared to NO reducing enzymes and metals is that immobilized heme groups do not reduce NH2OH further to NH3. Apparently, binding to an isolated heme group is insufficient to break the N–O bond.
AB - This paper discusses our work on the reduction of nitric oxide (NO) by heme groups immobilized on electrode surfaces, which has been conducted in search for selective NO reduction catalysts. Results show two reduction pathways, one leading to the formation of N2O and another leading to the formation of NH2OH. By changing the conditions (pH, potential, NO concentration and immobilization method), 100% selectivity toward either N2O or NH2OH can be obtained. A difference compared to NO reducing enzymes and metals is that immobilized heme groups do not reduce NH2OH further to NH3. Apparently, binding to an isolated heme group is insufficient to break the N–O bond.
U2 - 10.1002/jbm.b.30658
DO - 10.1002/jbm.b.30658
M3 - Article
VL - 81B
SP - 231
EP - 238
JO - Journal of Biomedical Materials Research, Part B: Applied Biomaterials
JF - Journal of Biomedical Materials Research, Part B: Applied Biomaterials
SN - 1552-4973
IS - 1
ER -