Biohybrid polymer capsules

S.F.M. van Dongen, H.P.M. de Hoog, R.J.R.W. Peters, M. Nallani, R.J.M. Nolte, J.C.M. van Hest

    Research output: Contribution to journalArticleAcademicpeer-review

    322 Citations (Scopus)

    Abstract

    An overview of the wide range of polymer-based capsules that have been constructed from synthetic and biological building blocks or from biological building blocks that are taken out of their natural environment, using both hyperbranched and self-assembly approaches, was reviewed. The capsules that are discussed can be considered as the simplest mimics of an organelle or cell and contain a cavity in which chemical reactions can take place or cargo can be stored. The chemical tool box available for constructing polymer micelles and polymersomes is much larger, and natural motifs have been actively incorporated into their designs. Regarding LbL, polymersome, or polymeric micelle nanoreactors, it can be predicted that nature's biocatalysts will be increasingly used for encapsulation in these synthetic systems, holding promise for future nanoscale diagnostic devices. One of the main challenges in this field will be the effective stimulation of responsive polymersomes since most stimuli reported thus far cannot be applied in living organisms.

    Original languageEnglish
    Pages (from-to)6212-6274
    Number of pages63
    JournalChemical Reviews
    Volume109
    Issue number11
    DOIs
    Publication statusPublished - 11 Nov 2009

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    Micelles
    Capsules
    Polymers
    Nanoreactors
    Encapsulation
    Self assembly
    Chemical reactions
    Enzymes

    Cite this

    van Dongen, S. F. M., de Hoog, H. P. M., Peters, R. J. R. W., Nallani, M., Nolte, R. J. M., & van Hest, J. C. M. (2009). Biohybrid polymer capsules. Chemical Reviews, 109(11), 6212-6274. https://doi.org/10.1021/cr900072y
    van Dongen, S.F.M. ; de Hoog, H.P.M. ; Peters, R.J.R.W. ; Nallani, M. ; Nolte, R.J.M. ; van Hest, J.C.M. / Biohybrid polymer capsules. In: Chemical Reviews. 2009 ; Vol. 109, No. 11. pp. 6212-6274.
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    van Dongen, SFM, de Hoog, HPM, Peters, RJRW, Nallani, M, Nolte, RJM & van Hest, JCM 2009, 'Biohybrid polymer capsules', Chemical Reviews, vol. 109, no. 11, pp. 6212-6274. https://doi.org/10.1021/cr900072y

    Biohybrid polymer capsules. / van Dongen, S.F.M.; de Hoog, H.P.M.; Peters, R.J.R.W.; Nallani, M.; Nolte, R.J.M.; van Hest, J.C.M.

    In: Chemical Reviews, Vol. 109, No. 11, 11.11.2009, p. 6212-6274.

    Research output: Contribution to journalArticleAcademicpeer-review

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    van Dongen SFM, de Hoog HPM, Peters RJRW, Nallani M, Nolte RJM, van Hest JCM. Biohybrid polymer capsules. Chemical Reviews. 2009 Nov 11;109(11):6212-6274. https://doi.org/10.1021/cr900072y