Biodegradable Polymersomes with Structure Inherent Fluorescence and Targeting Capacity for Enhanced Photo-Dynamic Therapy

Shoupeng Cao, Yifeng Xia, Jingxin Shao, Beibei Guo, Yangyang Dong, Imke A.B. Pijpers, Zhiyuan Zhong, Fenghua Meng (Corresponding author), Loai K.E.A. Abdelmohsen (Corresponding author), David S. Williams (Corresponding author), Jan C.M. van Hest (Corresponding author)

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Abstract

Biodegradable nanostructures displaying aggregation-induced emission (AIE) are desirable from a biomedical point of view, due to the advantageous features of loading capacity, emission brightness, and fluorescence stability. Herein, biodegradable polymers comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-P(CLgTMC)), with tetraphenylethylene pyridinium-TMC (PAIE) side chains have been developed, which self-assembled into well-defined polymersomes. The resultant AIEgenic polymersomes are intrinsically fluorescent delivery vehicles. The presence of the pyridinium moiety endows the polymersomes with mitochondrial targeting ability, which improves the efficiency of co-encapsulated photosensitizers and improves therapeutic index against cancer cells both in vitro and in vivo. This contribution showcases the ability to engineer AIEgenic polymersomes with structure inherent fluorescence and targeting capacity for enhanced photodynamic therapy.

Original languageEnglish
Pages (from-to)17629-17637
Number of pages9
JournalAngewandte Chemie - International Edition
Volume60
Issue number32
DOIs
Publication statusPublished - 2 Aug 2021

Bibliographical note

Funding Information:
The authors would like to acknowledge the ERC Advanced Grant Artisym 694120, the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035), the NWO-NSFC Advanced Materials (project 792.001.015), and the European Union's Horizon 2020 research and innovation program Marie Sklodowska-Curie Innovative Training Networks Nanomed (No. 676137) for funding. We thank the Ser Cymru II program for support of DSW; this project received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sk?odowska-Curie grant agreement No. 663830. This work was also supported by research funding from the National Natural Science Foundation of China (NSFC 51561135010). We also thank Alex Mason for help with Cryo-TEM measurements.

Keywords

  • aggregation-induced emission
  • biodegradable polymersomes
  • mitochondria targeting
  • photo-dynamic therapy
  • polycarbonates

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