Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

D. Lensen, E.C. Gelderblom, D.M. Vriezema, P. Marmottant, N. Verdonschot, M. Versluis, N. de Jong, J.C.M. Hest, van

Research output: Contribution to journalArticleAcademicpeer-review

62 Citations (Scopus)

Abstract

A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion.

Original languageEnglish
Pages (from-to)5417-5422
Number of pages6
JournalSoft Matter
Volume7
Issue number11
DOIs
Publication statusPublished - 7 Jun 2011
Externally publishedYes

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