Biodegradable fibre scaffolds incorporating water-soluble drugs and proteins

J. Ma, J. Meng, M. Simonet, N. Stingelin, T. Peijs, G.B. Sukhorukov

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

A new type of biodegradable drug-loaded fibre scaffold has been successfully produced for the benefit of water-soluble drugs and proteins. Model drug loaded calcium carbonate (CaCO3) microparticles incorporated into poly(lactic acid-co-glycolic acid) (PLGA) fibres were manufactured by co-precipitation of CaCO3 and the drug molecules, followed by electrospinning of a suspension of such drug-loaded microparticles in a PLGA solution. Rhodamine 6G and bovine serum albumin were used as model drugs for our release study, representing small bioactive molecules and protein, respectively. A bead and string structure of fibres was achieved. The drug release was investigated with different drug loadings and in different pH release mediums. Results showed that a slow and sustained drug release was achieved in 40 days and the CaCO3 microparticles used as the second barrier restrained the initial burst release.
Original languageEnglish
Article number205
Pages (from-to)1-9
JournalJournal of Materials Science: Materials in Medicine
Volume26
Issue number7
DOIs
Publication statusPublished - 2015

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